Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein

RMB: 1619 特惠 1619

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Catalog# HA211017

Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein

Product Information

Product name

Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein

Catalog No.

HA211017

Predicted molecular mass

71.7 kD

Protein construction description

A DNA sequence encoding the human Neuropilin-1/NRP1 protein (O14786-1) (Phe 22-Lys 644) was expressed with a His tag at the C-terminus.

Accession

O14786-1

Protein construction

Neuropilin-1/NRP1 (22-644) His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.