Product Information
Product name
Human IL-16, C-His Tag Protein
Catalog No.
HA210917
Predicted molecular mass
14.8 kD
Protein construction description
A DNA sequence encoding the human IL-16 protein (Q14005-1) (Met 1203-Ser 1332) was expressed with a His tag at the C-terminus
Accession
Q14005-1
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. IL-16 was originally described as a factor that could attract activated T cells in humans, it was previously called lymphocyte chemoattractant factor (LCF). Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including monocytes, eosinophils, and dendritic cells. The structure of IL-16 was determined following its cloning in 1994. This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor for mature IL-16.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
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Human MAPK12, C-His Tag Protein
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Human CEACAM-1/CD66a, C-His Tag (ECD) Protein
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Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein
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Human CD58/LFA-3, C-His Tag (ECD) Protein
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Human IFN-alpha/beta R2, C-His Tag (ECD) Protein
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Human IFN-alpha/beta R1, C-His (ECD) Protein
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Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein
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Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag Protein
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Human IL-1 RII, C-His Tag (ECD) Protein
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Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein
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Human IL12RB1, C-His Tag (ECD) Protein
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Human IL-17A, Tag Free Protein
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Human IFNA1/IFNA13, C-Tag Protein
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Human LTA, Tag Free Protein
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Human RAC1, C-Flag Tag Protein
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Human IL-9, C-Flag Tag Protein
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Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
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Human M-CSF/CSF1 (33-255), C His Tag Protein
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Human M-CSF/CSF1 (33-190), Tag Free Protein
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Human CD28, C-His Tag Protein
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Human IL-3, Tag Free Protein
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Human LAG-3, Tag Free Protein
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Human IL-2R alpha, Tag Free Protein
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Human CD2, N-Twin Strep, C-His, Flag Tag Protein
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Human IL-2RB/CD122, C-His Tag (ECD) Protein
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Reactivity: Human
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Human CD27/TNFRSF7, Tag Free Protein
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Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
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Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein
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Human Endoglin/CD105, C-His Tag (ECD) Protein
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Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
Application:
Reactivity: Human
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Conjugate:
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Application:
Reactivity: Human
Conjugate:
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