Product Information
Product name
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD) Protein
Catalog No.
HA210718
Predicted molecular mass
50.2 kD
Protein construction description
A DNA sequence encoding the human LILRB1/CD85j/ILT2 protein (Q8NHL6) (Gly 24-Vla 461) was expressed with both His and Flag tag at the C-terminus.
Accession
Q8NHL6
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human IL-13 R alpha 2/IL13RA2, Tag Free (ECD) Protein
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Human CCL5/RANTES, Tag Free Protein
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Human Neuropilin-1/NRP1, C-His Tag (ECD) Protein
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Human MAPK12, C-His Tag Protein
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Human CEACAM-1/CD66a, C-His Tag (ECD) Protein
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Human IL-33, C-His Tag Protein
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Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein
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Human LAIR1, N-Twin Strep, C-His, Flag Tag Protein
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Human IL17RA/CD217, C-His Tag (ECD) Protein
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Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein
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Human CD58/LFA-3, C-His Tag (ECD) Protein
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Reactivity: Human
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Human IFN-alpha/beta R2, C-His Tag (ECD) Protein
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Reactivity: Human
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Human IFN-alpha/beta R1, C-His (ECD) Protein
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Reactivity: Human
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Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD) Protein
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Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag Protein
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Human IL-1 RII, C-His Tag (ECD) Protein
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Human PRDM1, N-Twin Strep, C-His, Flag Tag Protein
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Human IL12RB1, C-His Tag (ECD) Protein
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Human IL-17A, Tag Free Protein
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Reactivity: Human
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Human RAC1, C-Flag Tag Protein
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Reactivity: Human
Conjugate:
Human CDC42, Tag Free Protein
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Reactivity: Human
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Human IL-18, Tag Free Protein
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Human BAFF/BLyS/TNFSF13B, Tag Free (ECD) Protein
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Human OX40/TNFRSF4, C-His Tag Protein
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Human CCL17/TARC, Tag Free Protein
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Human CCL3/MIP-1, Tag Free Protein
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Human Nectin-2, C-His Tag (ECD) Protein
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Human CD48, C-His Tag Protein
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Human IL-13, Tag Free Protein
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Human IL-9, C-Flag Tag Protein
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Human 5'-nucleotidase/CD73/NT5E, C-His Tag Protein
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Human CD28, C-His Tag Protein
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Human IL-3, Tag Free Protein
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Human CD155/PVR, C-His Tag (ECD) Protein
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Reactivity: Human
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Human ULBP1/NKG2DL1, C-His Tag Protein
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Reactivity: Human
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Human IL-3R alpha/CD123, C-His Tag Protein
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Human IL-5, C-His Tag Protein
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Human CCL11/Eotaxin, Tag Free Protein
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Reactivity: Human
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Human IL5RA, C-His Tag (ECD) Protein
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Human CD30/TNFRSF8, C-His, Flag Tag (ECD) Protein
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Human IL1RA, C-His Tag Protein
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Human Syndecan-1/CD138, C-His Tag (ECD) Protein
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Human CSK, C-His Tag Protein
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Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD) Protein
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Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD) Protein
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Human LAG-3, Tag Free Protein
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Human CD2, N-Twin Strep, C-His, Flag Tag Protein
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Human IL-2RB/CD122, C-His Tag (ECD) Protein
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Human IL-21, C-His, Flag Tag Protein
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Human IFN-gamma, C-His Tag Protein
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Reactivity: Human
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Human 4-1BB/TNFRSF9, C-His Tag Protein
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Reactivity: Human
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Human Siglec-7/CD328, C-His (ECD) Protein
Application:
Reactivity: Human
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Human B7-1/CD80, Tag Free Protein
Application:
Reactivity: Human
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Human CCL20, Tag Free Protein
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Human IL-1 beta/IL1B, C-His Tag Protein
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Human IL-4, Tag Free Protein
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Human IL-2, Tag Free Protein
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Human HVEM/TNFRSF14, Tag Free (ECD) Protein
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Application:
Reactivity: Human
Conjugate:
Human IL-4R, C-His, Tag (ECD) Protein
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CXCL9, Tag Free Protein
Application:
Reactivity: Human
Conjugate:
Human CCL2/MCP1, Tag Free Protein
Application:
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Human CTLA-4, C-His Tag Protein
Application:
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Human CD31/PECAM-1, C-His Tag Protein
Application:
Reactivity: Human
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Reactivity: Human
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Human VCAM-1 / CD106, C-His Tag Protein
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Application:
Reactivity: Human
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Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag Protein
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Reactivity: Human
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Human TREM1, C-Hia, Flag Tag Protein
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