Home
Human PMCA1/ATP2B1, C-His Tag
Human PMCA1/ATP2B1, C-His Tag Protein

Human PMCA1/ATP2B1, C-His Tag Protein

DATA SHEET
MSDS
COA

RMB: 599 特惠 1599 1599

产品规格

20μg

50μg

100μg

现在订购，【现货】

点击询价

联系我们

邮箱: sales@huabio.cn

电话: 0571-88062880

查找各地代理商

Catalog# HA210711

Human PMCA1/ATP2B1, C-His Tag Protein

Product Information

Product name

Human PMCA1/ATP2B1, C-His Tag Protein

Catalog No.

HA210711

Predicted molecular mass

24.5 kD

Protein construction description

A DNA sequence encoding the human PMCA1/ATP2B1 protein (P20020) (Thr 481-Asp 684) was expressed with a His tag at the C-terminus.

Accession

P20020

Protein construction

PMCA1/ATP2B1 (481-684) His

Source

E.coli

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.