beta Actin Rabbit Polyclonal Antibody
Catalog# R1207-1
beta Actin Rabbit Polyclonal Antibody
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WB
-
IF-Cell
-
IHC-P
-
FC
-
Human
-
Mouse
-
Rat
-
Zebrafish
-
bamboo
-
unconjugated
概述
产品名称
beta Actin Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
免疫原
Synthetic peptide within N-terminal residues of β-Actin.
种属反应性
Human, Mouse, Rat, Zebrafish, bamboo
验证应用
WB, IF-Cell, IHC-P, FC
分子量
Predicted band size: 42 kDa
阳性对照
HeLa cell lysate, A549 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, mouse lung tissue lysate, rat lung tissue lysate, HeLa, NIH/3T3, PC-12, human kidney tissue, human lung tissue, mouse kidney tissue, mouse lung tissue, rat kidney tissue, rat lung tissue, hybrid fish (crucian-carp) brain tissue, hybrid fish (crucian-carp) kidney tissue.
偶联
unconjugated
RRID
产品特性
形态
Liquid
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Immunogen affinity purified.
应用稀释度
-
WB
-
1:20,000
-
IF-Cell
-
1:100
-
IHC-P
-
1:2,000
-
FC
-
1:1,000
靶点
功能
Actins are highly conserved proteins involved in cell motility, structure and integrity. Actin has been found to be expressed in at least six isomeric forms. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. It is also expressed in the cytoplasm of non-muscle cells, functioning to control cell structure and motility. Beta actin is usually used as a loading control, for among others, the integrity of cells, protein degradation, in Western Blotting.
背景文献
1. Ponte P., Ng S.Y., Engel J., Gunning P., Kedes L."Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA." Nucleic Acids Res. 12:1687-1696(1984) Ohmori H., Toyama S., Toyama S."Direct proof that the primary site of action of cytochalasin on cell motility processes is actin."J. Cell Biol. 116:933-941(1992)
序列相似性
Belongs to the actin family.
翻译后修饰
ISGylated.; Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.; Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.; Methylated at His-73 by SETD3. Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).; [Actin, cytoplasmic 1, N-terminally processed]: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.; (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
亚细胞定位
Cytoskeleton
UNIPROT
别名
A26C1A antibody
A26C1B antibody
ACTB antibody
ACTB_HUMAN antibody
Actin beta antibody
Actin cytoplasmic 1 antibody
Actin, cytoplasmic 1, N-terminally processed antibody
Actx antibody
b actin antibody
Beta cytoskeletal actin antibody
展开A26C1A antibody
A26C1B antibody
ACTB antibody
ACTB_HUMAN antibody
Actin beta antibody
Actin cytoplasmic 1 antibody
Actin, cytoplasmic 1, N-terminally processed antibody
Actx antibody
b actin antibody
Beta cytoskeletal actin antibody
Beta-actin antibody
BRWS1 antibody
E430023M04Rik antibody
MGC128179 antibody
PS1TP5 binding protein 1 antibody
PS1TP5BP1 antibody
β-actin antibody
β actin antibody
折叠图片
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Western blot analysis of beta Actin on different lysates with Rabbit anti-beta Actin antibody (R1207-1) at 1/20,000 dilution.
Lane 1: HeLa cell lysate
Lane 2: A549 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: NIH/3T3 cell lysate
Lane 5: PC-12 cell lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Rat brain tissue lysate
Lane 8: Mouse lung tissue lysate
Lane 9: Rat lung tissue lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 42 kDa
Observed band size: 42 kDa
Exposure time: 30 seconds;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (R1207-1) at 1/20,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature. -
Immunocytochemistry analysis of HeLa cells labeling beta Actin with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI. Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunocytochemistry analysis of NIH/3T3 cells labeling beta Actin with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI. Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunocytochemistry analysis of PC-12 cells labeling beta Actin with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-beta Actin antibody (R1207-1) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI. Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunohistochemical analysis of paraffin-embedded human kidney tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded human lung tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded mouse lung tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded rat kidney tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded rat lung tissue with Rabbit anti-beta Actin antibody (R1207-1) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (R1207-1) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Western blot analysis of β-actin on different lysates using anti-β-actin antibody at 1/1,000 dilution.
Positive control:
Lane 1: hybrid fish (crucian-carp) brain tissue
Lane 2: hybrid fish (crucian-carp) kidney tissue
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
引文
-
Elucidating the Mechanism of Emodin in Treating Post‐Stroke Depression Through Network Pharmacology and Animal Experiments
期刊: CNS Neuroscience & Therapeutics
DOI: 10.1111/cns.70581
IF: 5
应用: WB
反应种属: Rat
发表时间: 2025 Sept
-
Targeted deprivation of STAT6 sensitizes acute lymphoblastic leukemia cells to cytarabine in vivo and in vitro: clinical implications
期刊: Cell Death & Disease
DOI: 10.1038/s41419-025-07981-7
IF: 9.6
应用: WB
反应种属: Human
发表时间: 2025 Sept
-
Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft
期刊: Cell Communication And Signaling
DOI: 10.1186/s12964-025-02497-1
IF: 8.9
应用: WB
反应种属: Human,Rat
发表时间: 2025 Nov
-
Oral delivery of dextran-modified albumin nanoparticles loaded with shikonin for targeted therapy of colorectal cancer
期刊: Discover Nano
DOI: 10.1186/s11671-025-04393-6
IF: 4.5
应用: WB
反应种属: Mouse
发表时间: 2025 Nov
-
4D Printed Hydrogel Expanders for Personalized and Accelerated Soft Tissue Regeneration
期刊: Advanced Materials
DOI: 10.1002/adma.202512662
IF: 26.8
应用: WB
反应种属: Rat
发表时间: 2025 Nov
-
Metabolomics and integrated network pharmacology analysis revealed multi-targeted anti-cancer effect of FuZhengXiaoJi Decoction against non-small cell lung cancer
期刊: Phytomedicine
DOI: 10.1016/j.phymed.2025.156855
IF: 6.7
应用: WB
反应种属: Mouse,Human
发表时间: 2025 May
-
Mg–Sc alloy promotes angiogenesis–osteogenesis coupling and ameliorates steroid-induced osteonecrosis of the femoral head
期刊: Rare Metals
DOI: 10.1007/s12598-025-03322-x
IF: 9.6
应用: WB
反应种属: Mouse,Human
发表时间: 2025 May
-
Swietenine improved the progression of diabetic nephropathy through inhibiting ferroptosis via activating Akt/GSK-3β/Nrf2 signaling pathway
期刊: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2025.119981
IF: 4.8
应用: WB
反应种属: Mouse
发表时间: 2025 May
-
A novel tumor-associated macrophage risk signature predicts prognosis and immunotherapy response in lung adenocarcinoma
期刊: American Journal Of Cancer Research
DOI: 10.62347/SQUF6988
IF: 3.6
应用: WB
反应种属: Human
发表时间: 2025 Mar
-
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway
期刊: European Journal Of Pharmacology
DOI: 10.1016/j.ejphar.2025.177501
IF: 4.2
应用: WB
反应种属: Rat
发表时间: 2025 Mar
-
LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers
期刊: Journal Of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5c00731
IF: 6.8
应用: WB
反应种属: Human
发表时间: 2025 Jun
-
Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway
期刊: Scientific Reports
DOI: 10.1038/s41598-025-03606-3
IF: 3.9
应用: WB
反应种属: Human
发表时间: 2025 Jul
-
CircMRP4 orchestrates podocytes injury via the miR-499-5p/RRAGB/mTORC1 axis in diabetic kidney disease
期刊: CELLULAR SIGNALLING
DOI: 10.1016/j.cellsig.2025.111611
IF: 3.7
应用: WB
反应种属: Mouse
发表时间: 2025 Jan
-
Bushen-Huoxue-Mingmu-Formula attenuates pressurization-induced retinal ganglion cell damage by reducing mitochondrial autophagy through the inhibition of the Pink1/Parkin pathway
期刊: Medicine
DOI:
IF: 1.3
应用: WB
反应种属: Rat
发表时间: 2025 Jan
-
Bushen-Huoxue-Mingmu-Formula attenuates pressurization-induced retinal ganglion cell damage by reducing mitochondrial autophagy through the inhibition of the Pink1/Parkin pathway
期刊: MEDICINE
DOI: 10.1097/MD.0000000000041257
IF: 1.4
应用: WB
反应种属: Rat
发表时间: 2025 Jan
-
Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice
期刊: Biomolecules & Therapeutics
DOI: 10.4062/biomolther.2024.061
IF: 3
应用: WB
反应种属: Mouse
发表时间: 2025 Feb
-
SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism
期刊: BMC Cancer
DOI: 10.1186/s12885-025-14644-5
IF: 3.4
应用: WB
反应种属: Human
发表时间: 2025 Aug
-
A Noninvasive Nanoeyedrop Therapy for the Inhibition of Uveal Melanoma: Tetrahedral Framework Nucleic Acid–Based Bioswitchable MicroRNA Delivery System
期刊: ACS Applied Nano Materials
DOI: 10.1021/acsnano.4c16427
IF: 15.8
应用: WB
反应种属: Human
发表时间: 2025 Apr
-
Mannose modified graphene oxide drug-delivery system targets cancer stem cells and tumor-associated macrophages to promote immunotherapeutic efficacy
期刊: Colloids And Surfaces B: Biointerfaces
DOI: 10.1016/j.colsurfb.2025.114710
IF: 5.4
应用: WB
反应种属: Human
发表时间: 2025 Apr
-
Identification of NMT1/MA/VPS15 signal pathway as potential therapeutic target in rat cerebral ischemia injury
期刊: Experimental Neurology
DOI: 10.1016/j.expneurol.2025.115252
IF: 4.6
应用: WB
反应种属: Rat
发表时间: 2025 Apr
-
Chinese yam polysaccharide enhances anti-PD-1 immunotherapy in colorectal cancer through alterations in the gut microbiota and metabolites
期刊: International Journal Of Biological Macromolecules
DOI: 10.1016/j.ijbiomac.2025.143323
IF: 7.7
应用: WB
反应种属: Mouse
发表时间: 2025 Apr
-
The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway
期刊: Molecular Basis Of Disease
DOI: https://doi.org/10.1016/j.bbadis.2024.167499
IF:
应用: WB
反应种属: Mouse
发表时间: 2024 Sep
-
Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models
期刊: EMBO Reports
DOI:
IF: 6.5
应用: WB
反应种属: Mouse
发表时间: 2024 Oct
-
Coronavirus M protein promotes mitophagy over virophagy by recruiting PDPK1 to phosphorylate SQSTM1 at T138
期刊: Nature Communications
DOI:
IF: 14.7
应用: WB
反应种属: Mouse
发表时间: 2024 Oct
-
Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway
期刊: Molecular Cancer
DOI:
IF: 27.7
应用: WB
反应种属: Mouse
发表时间: 2024 Nov
-
Fluoxetine Ameliorates Cognitive Deficits in High-Fat Diet Mice by Regulating BDNF Expression
期刊: ACS Chemical Neuroscience
DOI:
IF: 4.1
应用: WB
反应种属: Mouse
发表时间: 2024 Nov
-
The anti-non-small cell lung cancer effect of Diosbulbin B: targeting YY1 induced cell cycle arrest and apoptosis
期刊: Phytomedicine
DOI:
IF: 7.9
应用: WB
反应种属: Human
发表时间: 2024 May
-
Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases
期刊: Journal Of Medicinal Chemistry
DOI:
IF: 7.3
应用: WB
反应种属: Mouse
发表时间: 2024 May
-
Beneficial Effects of Oxymatrine from Sophora flavescens on Alleviating by Improving Inflammation and Ferroptosis
期刊: Journal Of Ethnopharmacology
DOI:
IF: 5.4
应用: WB
反应种属: Mouse
发表时间: 2024 May
-
Ghrelin regulates the endoplasmic reticulum stress signalling pathway in gestational diabetes mellitus
期刊: Biochemical And Biophysical Research Communications
DOI:
IF: 3.1
应用: WB
反应种属: Human
发表时间: 2024 Mar
-
Influential upregulation of KCNE4: Propelling cancer associated fibroblasts-driven colorectal cancer progression
期刊: Cancer Cell International
DOI:
IF: 5.8
应用: WB
反应种属: Mouse
发表时间: 2024 Mar
-
Discovery of novel peptide-dehydroepiandrosterone hybrids inducing endoplasmic reticulum stress with effective in vitro and in vivo anti-melanoma activities
期刊: European Journal Of Medicinal Chemistry
DOI:
IF: 6.7
应用: WB
反应种属: Mouse
发表时间: 2024 Mar
-
Macrophage Extracellular Traps Suppress Particulate Matter–Induced Airway Inflammation
期刊: American Journal Of Pathology
DOI: 10.1016/j.ajpath.2024.05.008
IF: 4.7
应用: WB
反应种属: Mouse
发表时间: 2024 Jun
-
SENP2-NDR2-p21 axis modulates lung cancer cell growth
期刊: European Journal Of Pharmacology
DOI: 10.1016/j.ejphar.2024.176761
IF: 4.2
应用:
反应种属:
发表时间: 2024 Jun
-
Hypoxia exacerbates the malignant transformation of gastric epithelial cells induced by long-term H. pylori infection
期刊: Microbiology Spectrum
DOI: 10.1128/spectrum.00311-24
IF: 3.7
应用: WB
反应种属: Human
发表时间: 2024 Jun
-
A novel trifluoromethyl quinoline derivative targeting SGK1 inducing autophagy and apoptosis via regulating mTOR/FOXO3a pathway in glioblastoma
期刊: Arabian Journal Of Chemistry
DOI:
IF: 5.3
应用: WB
反应种属: Human
发表时间: 2024 Jul
-
Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection
期刊: Nature Communications
DOI:
IF: 14.7
应用: WB
反应种属: Human
发表时间: 2024 Jul
-
Claudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression
期刊: Cell Communication And Signaling
DOI:
IF: 8.4
应用: WB
反应种属: Human,Mouse
发表时间: 2024 Jan
-
Adenosine A2A receptor antagonist KW6002 protects against A53T mutant alpha-synuclein-induced brain damage and neuronal apoptosis in Parkinson's disease mice by restoring autophagic flux
期刊: Neuroscience Letters
DOI:
IF: 2.5
应用: WB
反应种属: Mouse
发表时间: 2024 Jan
-
Hydrogel-immobilized nanotherapeutics: Inhibition of protective autophagy to amplify STING signals for postsurgical tumor immunotherapy
期刊: Chemical Engineering Journal
DOI:
IF: 15.1
应用: WB
反应种属: Mouse
发表时间: 2024 Jan
-
Sweet taste receptors play roles in artificial sweetener-induced enhanced urine output in mice
期刊: Npj Science Of Food
DOI: 10.1038/s41538-023-00236-9
IF: 6.3
应用:
反应种属:
发表时间: 2024 Jan
-
Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages
期刊: Tissue & Cell
DOI: 10.1016/j.tice.2024.102334
IF: 2.7
应用: WB
反应种属: Mouse
发表时间: 2024 Feb
-
Genome-wide CRISPR Screening Identifies the Pivotal Role of ANKRD42 in Colorectal Cancer Metastasis Through EMT Regulation
期刊:
DOI:
IF:
应用: WB
反应种属: Mouse
发表时间: 2024 Feb
-
SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD
期刊: Molecular Therapy
DOI:
IF: 12.1
应用: WB
反应种属: Mouse
发表时间: 2024 Dec
-
Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury
期刊: Journal Of Inflammation Research
DOI:
IF: 4.2
应用: WB
反应种属: Mouse
发表时间: 2024 Dec
-
LTBP2 silence suppresses glioblastoma proliferation and tumor growth of Xenograft tumor mice through modulating JAK2/STAT3 signaling pathway
期刊: Tissue & Cell
DOI:
IF: 2.7
应用: WB
反应种属: Mouse
发表时间: 2024 Dec
-
Geniposide modulates GSK3β to inhibit Th17 differentiation and mitigate endothelial damage in intracranial aneurysm
期刊: Phytotherapy Research
DOI: 10.1002/ptr.8320
IF: 6.1
应用: WB
反应种属: Mouse
发表时间: 2024 Aug
-
Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability
期刊: Drug Resistance Updates
DOI:
IF: 15.8
应用: WB
反应种属: Human
发表时间: 2024 Aug
-
Lycium barbarum glycopeptide ameliorates motor and visual deficits in autoimmune inflammatory diseases
期刊: Phytomedicine
DOI:
IF: 7.9
应用: WB
反应种属: Mouse
发表时间: 2024 Apr
-
Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury
期刊:
DOI:
IF: 4.5
应用: WB
反应种属: Mouse
发表时间: 2024 Apr
-
The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
期刊: Developmental Cell
DOI: 10.1016/j.devcel.2024.03.018
IF: 10.7
应用: WB
反应种属: Mouse,Human
发表时间: 2024 Apr
-
Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification
期刊: International Journal Of Biological Macromolecules
DOI:
IF: 8.2
应用: WB
反应种属: Human
发表时间: 2023 Oct
-
Nucleophosmin 1a translocated from nucleus to cytoplasm and facilitate GCRV replication
期刊: Fish & Shellfish Immunology
DOI:
IF: 4.7
应用: WB
反应种属: Fish
发表时间: 2023 Oct
-
Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3
期刊: Journal Of The Science Of Food And Agriculture
DOI: 10.1002/jsfa.13110
IF: 4.1
应用:
反应种属:
发表时间: 2023 Nov
-
PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis
期刊: Biochemical Pharmacology
DOI:
IF: 5.8
应用: WB
反应种属: Mouse
发表时间: 2023 May
-
Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment
期刊: European Journal Of Medicinal Chemistry
DOI:
IF: 7.088
应用: WB
反应种属: Human
发表时间: 2023 May
-
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
期刊: Leukemia
DOI:
IF: 11.3
应用: WB
反应种属: Human
发表时间: 2023 Jun
-
Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases
期刊: Molecular Therapy
DOI:
IF: 12.4
应用: WB
反应种属: Mouse
发表时间: 2023 Jul
-
MicroRNA-375 Mediated Regulation on Pre-mRNA Processing Factor 3 in Zebrafish Embryos Exposed to Di-(2-ethylhexyl)phthalate at Low Concentrations
期刊: Chemical Research In Toxicology
DOI:
IF:
应用: WB
反应种属: zebrafish
发表时间: 2023 Jan
-
A genome-wide CRISPR screen identifies the CCT chaperonin as a critical regulator of vesicle trafficking
期刊: FASEB Journal
DOI:
IF:
应用: WB
反应种属: Human
发表时间: 2023 Feb
-
Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
期刊: Cell Reports
DOI:
IF: 8.8
应用: WB
反应种属: Mouse
发表时间: 2023 Aug
-
Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut-Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination
期刊: Environmental Health Perspectives
DOI:
IF: 11.035
应用: WB
反应种属: Zebrafish
发表时间: 2023 Apr
-
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma
期刊: Frontiers In Medicine
DOI:
IF: 8.1
应用: WB
反应种属: Human
发表时间: 2023 Apr
-
Protective effects of epigallocatechin‐3‐o‐gallate combined with organic selenium against transforming growth factor‐beta 1‐induced fibrosis in LX‐2 cells
期刊: Journal Of Food Biochemistry
DOI:
IF: 4
应用: WB
反应种属: Human
发表时间: 2022 Sep
-
HRG-9 homologues regulate haem trafficking from haem-enriched compartments
期刊: Nature
DOI:
IF: 69.504
应用: WB
反应种属: Mouse
发表时间: 2022 Oct
-
Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota
期刊: Gut Microbes
DOI:
IF: 10.245
应用: WB
反应种属: Pig
发表时间: 2022 May
-
Antileukemic effects of topoisomerase I inhibitors mediated by de-SUMOylase SENP1
期刊: Biochimica Et Biophysica Acta (Bba) - Molecular Basis Of Disease
DOI: 10.1016/j.bbadis.2022.166492
IF: 6.633
应用: WB
反应种属: Human
发表时间: 2022 Jul
-
Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication
期刊: Journal Of Molecular Cell Biology
DOI:
IF: 6.216
应用: WB
反应种属: Zebrafish
发表时间: 2022 Jan
-
Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells
期刊: International Journal Of Molecular Sciences
DOI:
IF: 6.208
应用: WB
反应种属: Human
发表时间: 2022 Dec
-
Novel Dimeric Architecture of an IFN-γ–Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish
期刊: Journal Of Immunology
DOI:
IF: 4.4
应用: WB
反应种属: Human
发表时间: 2022 Dec
-
Streptococcus pneumoniae promotes migration and invasion of A549 cells in vitro by activating mTORC2/AKT through up-regulation of DDIT4 expression
期刊: Frontiers In Microbiology
DOI:
IF: 6.064
应用: WB
反应种属: Human
发表时间: 2022 Dec
-
Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress
期刊: Animals
DOI:
IF: 3.231
应用: WB
反应种属: Pig
发表时间: 2022 Aug
-
Lactobacillus plantarum postbiotics trigger AMPK-dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation
期刊: Journal Of Cellular Physiology
DOI:
IF: 6.513
应用: WB
反应种属: Pig
发表时间: 2022 Apr
-
Nonplanar Helicene Benzo[4]Helicenium for the Precise Treatment of Renal cell Carcinoma
期刊: Small Methods
DOI: 10.1002/smtd.202100770
IF: 14.188
应用: WB
反应种属: Human
发表时间: 2021 Sept
-
An endoparasitoid uses its egg surface proteins to regulate its host immune response
期刊: Insect Science
DOI: 10.1111/1744-7917.12978
IF: 3.262
应用: WB
反应种属: Cotesia chilonis
发表时间: 2021 Oct
-
Curcumol inhibits malignant biological behaviors and TMZ-resistance of glioma cells via reducing long noncoding RNA FoxD2-As1 promoted EZH2 activation
期刊: Aging (Albany Ny)
DOI:
IF: 5.2
应用: WB
反应种属: Mouse
发表时间: 2021 Nov
-
Proteomic analysis of Laodelphax striatellus in response to Rice stripe virus infection reveal a potential role of ZFP36L1 in restriction of viral proliferation
期刊: Journal Of Proteomics
DOI: 10.1016/j.jprot.2021.104184
IF: 4.044
应用: WB
反应种属: Laodelphax striatellus
发表时间: 2021 Mar
-
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response. Nucleic acids research, 49(10), 5537–5552.
期刊: Nucleic Acids Research
DOI:
IF: 16.971
应用: WB
反应种属: Mouse
发表时间: 2021 Jun
-
Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway. Frontiers in pharmacology, 12, 690736.
期刊: Frontiers In Pharmacology
DOI:
IF:
应用: WB
反应种属: Mouse
发表时间: 2021 Jun
-
FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway. Journal of Cancer, 12(17), 5345–5354.
期刊: Journal Of Cancer
DOI:
IF: 4.204
应用: WB
反应种属: Human
发表时间: 2021 Jul
-
Circadian clock gene BMAL1 reduces urinary calcium oxalate stones formation by regulating NRF2/HO-1 pathway. Life sciences, 265, 118853.
期刊:
DOI:
IF:
应用: WB
反应种属: Human
发表时间: 2021 Jan
-
Multi-omics analysis identifies potential mechanisms of AURKB in mediating poor outcome of lung adenocarcinoma.
期刊: Aging (Albany Ny)
DOI:
IF: 5.955
应用: WB
反应种属: Human
发表时间: 2021 Feb
-
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin. Molecular cancer, 20(1), 62.
期刊: Molecular Cancer
DOI:
IF:
应用: WB
反应种属: Mouse
发表时间: 2021 Apr
-
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3
期刊: Autophagy
DOI: 10.1080/15548627.2020.1817279
IF: 9.77
应用: WB
反应种属: Mouse,Chicken
发表时间: 2020 Sept
-
Liver injury in septic mice were suppressed by a camptothecin-bile acid conjugate via inhibiting NF-κB signaling pathway. Life sciences, 257, 118130.
期刊: Life Sciences
DOI:
IF: 3.647
应用: WB
反应种属: Mouse
发表时间: 2020 Sep
-
Metformin Prevents Follicular Atresia in Aging Laying Chickens through Activation of PI3K/AKT and Calcium Signaling Pathways
期刊: Oxidative Medicine And Cellular Longevity
DOI:
IF: 5.076
应用: WB,IF,IHC-P
反应种属: Chicken
发表时间: 2020 Nov
-
p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis
期刊: Cell Death & Disease
DOI:
IF: 6.304
应用: WB
反应种属: Zebrafish
发表时间: 2020 Jul
-
Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line
期刊: Current Gene Therapy
DOI:
IF: 3.6
应用: WB
反应种属: Human
发表时间: 2020
-
Selective Killing of Cancer Cells by Nonplanar Aromatic Hydrocarbon-Induced DNA Damage
期刊: Advanced Science
DOI:
IF: 15.804
应用: WB
反应种属: Human
发表时间: 2019 Sep
-
Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.
期刊: Brain Research
DOI:
IF: 2.929
应用: WB
反应种属: Rat
发表时间: 2019 Jul
-
Production and Function of Different Regions from Mytichitin-1 of Mytilus coruscus
期刊: Fish & Shellfish Immunology
DOI:
IF: 3.185
应用: WB
反应种属: Mytilus
发表时间: 2019 Jan
-
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
期刊: International Journal Of Biochemistry And Cell Biology
DOI:
IF: 3.144
应用: WB
反应种属: Human
发表时间: 2019 Apr
-
Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus)
期刊: Medical Science Monitor
DOI:
IF: 1.59
应用: WB
反应种属: Mouse
发表时间: 2018 Sep
-
Qingchang Suppository Ameliorates Colonic Vascular Permeability in Dextran-Sulfate-Sodium-Induced Colitis
期刊: Frontiers In Pharmacology
DOI:
IF: 3.83
应用: WB
反应种属: Rat
发表时间: 2018 Oct
-
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice
期刊: Neurotherapeutics
DOI:
IF: 5.719
应用: WB
反应种属: Mouse
发表时间: 2018 Oct
-
Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis
期刊: PLoS Genetics
DOI:
IF: 6.1
应用: WB
反应种属: Zebrafish
发表时间: 2018 Jul
-
MiR‐17 family‐mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling
期刊: Journal Of Cellular And Molecular Medicine
DOI:
IF: 4.30
应用: WB
反应种属: Human,Rat
发表时间: 2018 Dec
-
Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil
期刊: Journal Of Cellular And Molecular Medicine
DOI:
IF: 4.30
应用: WB
反应种属: Human
发表时间: 2018 Dec
-
Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells
期刊: Molecular Medicine Reports
DOI: 10.3892/mmr.2016.5249
IF: 1.559
应用: WB
反应种属: Human
发表时间: 2016 May
-
Liver-Enriched Gene 1,a Glycosylated Secretory Protein,Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish
期刊: PLoS Genetics
DOI:
IF: 6.7
应用: IF,WB
反应种属: Zebrafish
发表时间: 2016 Feb
-
Immune response of peroxinectin of chinese mitten crab eriocheir sinensis to exterior stimulation
期刊: Developmental And Comparative Immunology
DOI:
IF: 3.218
应用: WB
反应种属: Eriocheir sinensis
发表时间: 2015 Jul
-
Cancer-Associated Fibroblasts in a Human HEp-2 Established Laryngeal Xenografted Tumor Are Not Derived from Cancer Cells through Epithelial-Mesenchymal Transition,Phenotypically Activated but Karyotypically Normal
期刊: Public Library Of Science One
DOI:
IF: 3.2
应用: WB
反应种属: Human
发表时间: 2015 Feb
-
Autophagy protects against palmitate-induced apoptosis in hepatocytes
期刊: Cell And Bioscience
DOI:
IF: 3.6
应用: WB
反应种属: Human
发表时间: 2014 May
-
Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells
期刊: Scientific Reports
DOI:
IF: 5.6
应用: WB
反应种属: Human
发表时间: 2014 Jun
-
Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fraction
期刊: International Journal Of Oncology
DOI: 10.3892/ijo.2014.2307
IF: 2.773
应用: WB
反应种属: Human
发表时间: 2014 Feb
-
Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma Epithelia
期刊: Public Library Of Science One
DOI:
IF: 3.5
应用: WB
反应种属: Human
发表时间: 2013 Jun
-
Cooperation of side population cells with CD133 to enrich cancer stem cells in a laryngeal cancer cell line
期刊: Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck
DOI: 10.1002/hed.23447
IF: 2.833
应用: WB
反应种属: Human
发表时间: 2013 Aug
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