Human IL-1 beta/IL1B, C-His Tag
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Product Information
Product name
Human IL-1 beta/IL1B, C-His Tag
Catalog No.
HA210576
Predicted molecular mass
18.8 kD
Protein construction description
A DNA sequence encoding the human IL-1 beta / IL1B protein (P01584) (Ala 117-Ser 269) was expressed with a His tag at the C-terminus.
Accession
P01584
Protein construction
Source
HEK293
Bio Activity
Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.2-2 ng/mL.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human IL-8/CXCL8 Tag Free
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Human EPCR/PROCR/CD201, C-His, Flag Tag (ECD)
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Human CDCP1/CD318, N-Twin Strep, C-His, Flag Tag
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Human CD200, C-His Tag (ECD)
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Human IL-18 BPa, C-His Tag
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Human IL-22, C-His, Flag Tag
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Human IL1RL1/DER4/ST2, C-His (ECD)
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Reactivity: Human
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Human IL-17F, Tag Free
Application:
Reactivity: Human
Conjugate:
Human EGF, Tag Free
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Reactivity: Human
Conjugate:
Human LILRB4/ILT3, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human IL-4R, C-His, Tag (ECD)
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Reactivity: Human
Conjugate:
Human IL-10, C-His Tag
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Reactivity: Human
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Human IFNA1/IFNA13, C-Tag
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Reactivity: Human
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Human CXCL10, C-Flag Tag
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Reactivity: Human
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Human LTA, Tag Free
Application:
Reactivity: Human
Conjugate:
Human HSPA1A, Tag Free
Application:
Reactivity: Human
Conjugate:
Human RAC1, C-Flag Tag
Application:
Reactivity: Human
Conjugate:
Human CDC42, Tag Free
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Reactivity: Human
Conjugate:
Human IL-15, C-Flag Tag
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Reactivity: Human
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Human CD207, C-Flag Tag
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Reactivity: Human
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Human ATF6, Tag Free
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Reactivity: Human
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Human NCAM1/CD56, Tag Free (ECD)
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Reactivity: Human
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Human CD5, Tag Free (ECD)
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Reactivity: Human
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Human IL1RA, C-His Tag
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Reactivity: Human
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Human CXCL1, Tag Free
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Reactivity: Human
Conjugate:
Human TIE2/TEK, C-His, Flag Tag (ECD)
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Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, Tag Free (ECD)
Application:
Reactivity: Human
Conjugate:
Human MMP-3, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human CTLA-4, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human CXCL5, Tag Free
Application:
Reactivity: Human
Conjugate:
Human CD31/PECAM-1, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human TRAIL/TNFSF10, C-His Tag
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Reactivity: Human
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Human IP-10/CXCL10, Tag Free
Application:
Reactivity: Human
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Human CCL3/MIP-1, Tag Free
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Reactivity: Human
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Human MMP-1, C-Flag
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Reactivity: Human
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Human CXCL2/GRO beta, Tag Free
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Reactivity: Human
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Human IL-13, Tag Free
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Reactivity: Human
Conjugate:
Human IL-9, C-Flag Tag
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Reactivity: Human
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Human CD28, C-His Tag
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Reactivity: Human
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Human PD-1, C-His Tag
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Reactivity: Human
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Human IL-3, Tag Free
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Reactivity: Human
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Human CD58/LFA-3, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
Human CXCL9, Tag Free
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Reactivity: Human
Conjugate:
Human CEACAM-1/CD66a, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
Human TNF RI/TNFRSF1A, Tag Free (ECD)
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Reactivity: Human
Conjugate:
Human IL17RA/CD217, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human MAPK6, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
Human IL-7, C-His, Flag Tag
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Reactivity: Human
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Human TRAF3, C-His Tag
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Reactivity: Human
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Human IFN-alpha/beta R2, C-His Tag (ECD)
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Reactivity: Human
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Human cIAP-2/BIRC3, N-Twin Strep, C-His, Flag Tag
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Reactivity: Human
Conjugate:
Human IFN-alpha/beta R1, C-His (ECD)
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Reactivity: Human
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Human IL-6, C-His Tag
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Reactivity: Human
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Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human CD30/TNFRSF8, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human IL12B/P40, C-His Tag
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Reactivity: Human
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Human PPID, C-His Tag
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Reactivity: Human
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Human KIF5B, N-Twin Strep, C-His Tag
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Reactivity: Human
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Human IL-1 RII, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human CYLD, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human GM-CSF, Tag Free
Application:
Reactivity: Human
Conjugate:
Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human MAP4K1/HPK1, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human IL5RA, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human IL12RB1, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human GADD45A, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human CCL3L1, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, Tag Free
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma, C-His Tag
Application:
Reactivity: Human
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Human IL-4, Tag Free
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Reactivity: Human
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Human IL-2R alpha, Tag Free
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Reactivity: Human
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Human IL-18, Tag Free
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Human DVL2, C Twin Strep, Flag
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Human VEGF165, Tag Free
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Human CCL2/MCP1, Tag Free
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Human IL-2, Tag Free
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Human GADD45B, N-Twin Strep, C-His, Flag Tag
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Human IL-6, Tag Free
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Reactivity: Human
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Human CD27/TNFRSF7, Tag Free
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Reactivity: Human
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Human ANPEP/CD13, Tag Free (ECD)
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Reactivity: Human
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Human OX40/TNFRSF4, C-His Tag
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Reactivity: Human
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Human 4-1BB/TNFRSF9, C-His Tag
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Human TREM1, C-Hia, Flag Tag
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Human CCL11/Eotaxin, Tag Free
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Human PD-L1/B7-H1, C-hFc Tag
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Human BAFF/BLyS/TNFSF13B, Tag Free (ECD)
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Human CD48, C-His Tag
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Reactivity: Human
Conjugate:
Human 5'-nucleotidase/CD73/NT5E, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IL-16, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human M-CSF/CSF1 (33-255), C His Tag
Application:
Reactivity: Human
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Human IL-31, C-Flag Tag
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Reactivity: Human
Conjugate:
Human MAPK12, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IFN-gamma R1, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human CSK, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human COX5A, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IL-2RB/CD122, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human CRKL, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human TGF-beta RII, Tag Free (ECD)
Application:
Reactivity: Human
Conjugate:
Human IL-5, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human HCLS1, N-Strep II, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IL-17A, Tag Free
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD)
Application:
Reactivity: Human
Conjugate:
Human CD2, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human LAIR1, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human IL-7, Tag Free
Application:
Reactivity: Human
Conjugate:
Human TNF-alpha, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human Angiopoietin-1/ANGPT1, Tag Free
Application:
Reactivity: Human
Conjugate:
Human CCL17/TARC, Tag Free
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Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free
Application:
Reactivity: Human
Conjugate:
Human Nectin-2, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human M-CSF/CSF1 (33-190), Tag Free
Application:
Reactivity: Human
Conjugate:
Human VEGF121, Tag Free
Application:
Reactivity: Human
Conjugate:
Human P-Selectin/CD62P, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human PRDM1, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human EIF2AK3/PERK, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag
Application:
Reactivity: Human
Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IL-2, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD)
Application:
Reactivity: Human
Conjugate:
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