Human CTLA-4, C-His Tag
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Product Information
Product name
Human CTLA-4, C-His Tag
Catalog No.
HA210885
Predicted molecular mass
14.9 kD
Protein construction description
A DNA sequence encoding the human CTLA-4 protein (P16410) (Lys 36-Asp 161) was expressed with a His tag at the C-terminus
Accession
P16410
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as rheumatoid arthritis, autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In systemic lupus erythematosus (SLE), the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active SLE. Germline haploinsufficiency of CTLA-4 leads to CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration), a rare genetic disorder of the immune system. Symptomatic patients with CTLA-4 mutations are characterized by an immune dysregulation syndrome including extensive T cell infiltration in a number of organs, including the gut, lungs, bone marrow, central nervous system. Once a diagnosis is made, the treatment is based on an individual’s clinical condition and may include standard management for autoimmunity and immunoglobulin deficiencies. The comparatively higher binding affinity of CTLA-4 than CD28 has made it a potential therapy for autoimmune diseases.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human NCAM1/CD56, Tag Free (ECD)
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Human CD5, Tag Free (ECD)
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Human IL1RA, C-His Tag
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Human CXCL1, Tag Free
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Human TIE2/TEK, C-His, Flag Tag (ECD)
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Human HVEM/TNFRSF14, Tag Free (ECD)
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Human MMP-3, C-His, Flag Tag
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Human CXCL5, Tag Free
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Human CD31/PECAM-1, C-His Tag
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Reactivity: Human
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Human TRAIL/TNFSF10, C-His Tag
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Reactivity: Human
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Human IP-10/CXCL10, Tag Free
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Reactivity: Human
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Human CCL3/MIP-1, Tag Free
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Human MMP-1, C-Flag
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Human CXCL2/GRO beta, Tag Free
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Human CD58/LFA-3, C-His Tag (ECD)
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Human CXCL9, Tag Free
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Human CEACAM-1/CD66a, C-His Tag (ECD)
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Human TNF RI/TNFRSF1A, Tag Free (ECD)
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Human IL-1 beta/IL1B, C-His Tag
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Human IL17RA/CD217, C-His Tag (ECD)
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Human MAPK6, C-His Tag
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Reactivity: Human
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Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD)
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Reactivity: Human
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Human IL-7, C-His, Flag Tag
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Reactivity: Human
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Human TRAF3, C-His Tag
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Reactivity: Human
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Human IFN-alpha/beta R2, C-His Tag (ECD)
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Human IFN-alpha/beta R1, C-His (ECD)
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Human IL-6, C-His Tag
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Human IL-1 RII, C-His Tag (ECD)
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Human CYLD, C-His Tag
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Human TNF-alpha, Tag Free
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Human IFN-gamma, C-His Tag
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Human IL-4, Tag Free
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Human IL-2R alpha, Tag Free
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Human IL-18, Tag Free
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Human VEGF165, Tag Free
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Human IL-2, Tag Free
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Human CD27/TNFRSF7, Tag Free
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Human IL-7, Tag Free
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Human TNF-alpha, C-His Tag
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Human Angiopoietin-1/ANGPT1, Tag Free
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Human CCL17/TARC, Tag Free
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Reactivity: Human
Conjugate:
Human CXCL12/SDF-1, Tag Free
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Conjugate:
Human Nectin-2, C-His Tag (ECD)
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Human M-CSF/CSF1 (33-190), Tag Free
Application:
Reactivity: Human
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Human VEGF121, Tag Free
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Human P-Selectin/CD62P, C-His Tag (ECD)
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Reactivity: Human
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Application:
Reactivity: Human
Conjugate:
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Reactivity: Human
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Reactivity: Human
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