Human ICAM-1/CD54, C-His Tag (ECD)
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Product Information
Product name
Human ICAM-1/CD54, C-His Tag (ECD)
Catalog No.
HA210857
Predicted molecular mass
50.9 kD
Protein construction description
A DNA sequence encoding the human ICAM-1/CD54 protein (P05362) (Gln 28-Glu 480) was expressed with a His tag at the C-terminus.
Accession
P05362
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play important, yet separate, roles in embryogenesis and development. The intracellular adhesion molecule-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the beta2alpha1 and beta2alphaM Integrins. ICAM-2 functions as a ligand for lymphocyte function-associated antigen-1 (LFA-1) and is involved in leukocyte adhesion. ICAM-3 is highly expressed on the surface of human eosinophils and, when bound to ligand, may inhibit eosinophil inflammatory responses and survival. ICAM-4, also known as LW glycoprotein, interacts with Integrins alphaLbeta2, alphaMbeta2, alpha4beta1, the alphaV family and alphaIIbbeta3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM-5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecule for leukocyte binding in the central nervous system.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human IL-17F, Tag Free
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Human IL-10, C-His Tag
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Human LTA, Tag Free
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Human NRG1, C-Flag (176-246)
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Human RAC1, C-Flag Tag
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Human CDC42, Tag Free
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Human NRG1, Tag Free
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Human IL-15, C-Flag Tag
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Human CD207, C-Flag Tag
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Human NCAM1/CD56, Tag Free (ECD)
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Human CD5, Tag Free (ECD)
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Human IL1RA, C-His Tag
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Human CXCL1, Tag Free
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Human TIE2/TEK, C-His, Flag Tag (ECD)
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Human HVEM/TNFRSF14, Tag Free (ECD)
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Reactivity: Human
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Human MMP-3, C-His, Flag Tag
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Human CTLA-4, C-His Tag
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Human CD31/PECAM-1, C-His Tag
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Human CCL3/MIP-1, Tag Free
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Human CXCL2/GRO beta, Tag Free
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Human IL-13, Tag Free
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Human IL-9, C-Flag Tag
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Human CD28, C-His Tag
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Human IL-3, Tag Free
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Human CD58/LFA-3, C-His Tag (ECD)
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Human CXCL9, Tag Free
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Human CEACAM-1/CD66a, C-His Tag (ECD)
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Reactivity: Human
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Human TNF RI/TNFRSF1A, Tag Free (ECD)
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Reactivity: Human
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Human IL-1 beta/IL1B, C-His Tag
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Human IL17RA/CD217, C-His Tag (ECD)
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Human MAPK6, C-His Tag
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Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD)
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Human TRAF3, C-His Tag
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Human IFN-alpha/beta R2, C-His Tag (ECD)
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Human IFN-alpha/beta R1, C-His (ECD)
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Human CD30/TNFRSF8, C-His, Flag Tag (ECD)
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Human IL12B/P40, C-His Tag
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Human Annexin A6/ANXA6, N-Twin Strep, C-His, Flag Tag
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Human IL-1 RII, C-His Tag (ECD)
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Human NR4A2/NURR1, C-His Tag
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Human CYLD, C-His Tag
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Human GM-CSF, Tag Free
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Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD)
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Human IL5RA, C-His Tag (ECD)
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Human IL12RB1, C-His Tag (ECD)
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Human GADD45A, N-Twin Strep, C-His, Flag Tag
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Human CCL3L1, N-Twin Strep, C-His, Flag Tag
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Human CCL2/MCP1, Tag Free
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Human IL-2, Tag Free
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Human 4-1BB/TNFRSF9, C-His Tag
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Human 5'-nucleotidase/CD73/NT5E, C-His Tag
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Human IL-31, C-Flag Tag
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Human SPR, C-His Tag
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Human MAPK12, C-His Tag
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Conjugate:
Human IFN-gamma R1, C-His Tag (ECD)
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Human CSK, C-His Tag
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Human IL-2RB/CD122, C-His Tag (ECD)
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Human CASQ2, Tag Free
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Human VSNL1, C-His Tag
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Reactivity: Human
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Human IL-5, C-His Tag
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Human HCLS1, N-Strep II, C-His Tag
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Human CD63, Tag Free (ECD)
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