Human IL-1 alpha/IL1A, C-His, Flag Tag
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Product Information
Product name
Human IL-1 alpha/IL1A, C-His, Flag Tag
Catalog No.
HA210602
Predicted molecular mass
20.7 kD
Protein construction description
A DNA sequence encoding the human IL-1 alpha/IL1A protein (P01583) (Ser 113-Ala 271) was expressed with both His, Flag tag at the C-terminus.
Accession
P01583
Protein construction
Source
HEK293
Bio Activity
Testing in progress.
Purity
>95% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Species
Human
Background
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Usage guide
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Storage
Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution
Reconstitute at 250 μg/ml in sterile water.
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Human LILRB4/ILT3, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human IL-4R, C-His, Tag (ECD)
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Human IL-10, C-His Tag
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Human IFNA1/IFNA13, C-Tag
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Human CXCL10, C-Flag Tag
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Human LTA, Tag Free
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Human HSPA1A, Tag Free
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Human RAC1, C-Flag Tag
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Human CDC42, Tag Free
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Reactivity: Human
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Human IL-15, C-Flag Tag
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Reactivity: Human
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Human CD207, C-Flag Tag
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Human ATF6, Tag Free
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Human NCAM1/CD56, Tag Free (ECD)
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Human CD5, Tag Free (ECD)
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Human IL1RA, C-His Tag
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Human CXCL1, Tag Free
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Human TIE2/TEK, C-His, Flag Tag (ECD)
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Human HVEM/TNFRSF14, Tag Free (ECD)
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Reactivity: Human
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Human MMP-3, C-His, Flag Tag
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Reactivity: Human
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Human CTLA-4, C-His Tag
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Reactivity: Human
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Human CXCL5, Tag Free
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Reactivity: Human
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Human CD31/PECAM-1, C-His Tag
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Reactivity: Human
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Human TRAIL/TNFSF10, C-His Tag
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Reactivity: Human
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Human IP-10/CXCL10, Tag Free
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Human CCL3/MIP-1, Tag Free
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Human MMP-1, C-Flag
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Human CXCL2/GRO beta, Tag Free
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Human IL-13, Tag Free
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Human IL-9, C-Flag Tag
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Human CD28, C-His Tag
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Human PD-1, C-His Tag
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Human IL-3, Tag Free
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Human CD58/LFA-3, C-His Tag (ECD)
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Human CXCL9, Tag Free
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Human CEACAM-1/CD66a, C-His Tag (ECD)
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Reactivity: Human
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Human TNF RI/TNFRSF1A, Tag Free (ECD)
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Reactivity: Human
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Human IL-1 beta/IL1B, C-His Tag
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Reactivity: Human
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Human IL17RA/CD217, C-His Tag (ECD)
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Reactivity: Human
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Human IGFBP3/IBP3, C-His, Flag Tag
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Human MAPK6, C-His Tag
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Reactivity: Human
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Human ICOS Ligand/B7-H2/ICOSLG, C-His Tag (ECD)
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Human IL-7, C-His, Flag Tag
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Human TRAF3, C-His Tag
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Human IFN-alpha/beta R2, C-His Tag (ECD)
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Human IFN-alpha/beta R1, C-His (ECD)
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Human IL-6, C-His Tag
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Human LILRB2/CD85d/ILT4, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human CD30/TNFRSF8, C-His, Flag Tag (ECD)
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Human IL12B/P40, C-His Tag
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Human PPID, C-His Tag
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Human KIF5B, N-Twin Strep, C-His Tag
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Human IL-1 RII, C-His Tag (ECD)
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Human CYLD, C-His Tag
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Human GM-CSF, Tag Free
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Reactivity: Human
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Human LILRB1/CD85j/ILT2, C-His, Flag Tag (ECD)
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Reactivity: Human
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Human MAP4K1/HPK1, N-Twin Strep, C-His, Flag Tag
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Human IL5RA, C-His Tag (ECD)
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Human IL12RB1, C-His Tag (ECD)
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Human GADD45A, N-Twin Strep, C-His, Flag Tag
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Reactivity: Human
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Human CCL3L1, N-Twin Strep, C-His, Flag Tag
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Human TNF-alpha, Tag Free
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Human IFN-gamma, C-His Tag
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Human IL-4, Tag Free
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Human IL-2R alpha, Tag Free
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Human IL-18, Tag Free
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Human VEGF165, Tag Free
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Human IL-2, Tag Free
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Human IL-6, Tag Free
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Human CD27/TNFRSF7, Tag Free
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Human ANPEP/CD13, Tag Free (ECD)
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Human OX40/TNFRSF4, C-His Tag
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Human 4-1BB/TNFRSF9, C-His Tag
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Human CD48, C-His Tag
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Human 5'-nucleotidase/CD73/NT5E, C-His Tag
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Human CSK, C-His Tag
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Reactivity: Human
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Human COX5A, C-His Tag
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Reactivity: Human
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Human IL-2RB/CD122, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
Human CRKL, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human CD2, C-His, Flag Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human TGF-beta RII, Tag Free (ECD)
Application:
Reactivity: Human
Conjugate:
Human IL-5, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human HCLS1, N-Strep II, C-His Tag
Application:
Reactivity: Human
Conjugate:
Human IL-17A, Tag Free
Application:
Reactivity: Human
Conjugate:
Human CD63, Tag Free (ECD)
Application:
Reactivity: Human
Conjugate:
Human CD2, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human CD272/BTLA, C-His, Flag Tag (ECD)
Application:
Reactivity: Human
Conjugate:
Human LAIR1, N-Twin Strep, C-His, Flag Tag
Application:
Reactivity: Human
Conjugate:
Human IL-21, C-His, Flag Tag
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Reactivity: Human
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Human IL-7, Tag Free
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Human TNF-alpha, C-His Tag
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Human Angiopoietin-1/ANGPT1, Tag Free
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Human CXCL12/SDF-1, Tag Free
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Human Nectin-2, C-His Tag (ECD)
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Reactivity: Human
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Reactivity: Human
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Human VEGF121, Tag Free
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Human P-Selectin/CD62P, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
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Reactivity: Human
Conjugate:
Human E-Cadherin, C-His Tag (ECD)
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Reactivity: Human
Conjugate:
Human EIF2AK3/PERK, C-His Tag
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Reactivity: Human
Conjugate:
Human HVEM/TNFRSF14, C-Flag Tag
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Conjugate:
Human Interferon alpha-2/IFNA2, C-His Tag
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Reactivity: Human
Conjugate:
Human IL-2, C-His Tag
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Reactivity: Human
Conjugate:
Human G-CSF, C-His Tag
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Reactivity: Human
Conjugate:
Human ICAM-1/CD54, C-His Tag (ECD)
Application:
Reactivity: Human
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