Skip to content

Iba1 Recombinant Antibody [JM36-62] - Chicken IgY (Chimeric)

RMB: 699 特惠 1500

产品规格

现在订购，【少量现货】

点击询价

联系我们

邮箱: sales@huabio.cn

电话: 0571-88062880

查找各地代理商

Catalog# HA601376

Iba1 Recombinant Antibody [JM36-62] - Chicken IgY (Chimeric)

Application

  • IHC-Fr

Reactivity

  • Mouse

  • Rat

Predicted reactivity

  • Pig

  • Cynomolgus monkey

预测的种属支持售后

概述

产品名称

Iba1 Recombinant Antibody [JM36-62] - Chicken IgY (Chimeric)

抗体类型

Recombinant Chimeric Antibody

免疫原

Synthetic peptide within N-terminal human Iba1.

产品特异性

This Chicken Recombinant monoclonal chimeric antibody has been engineered from a HiMab parent antibody (ET1705-78). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed FC-reactive secondary antibodies are recommended.

种属反应性

Mouse, Rat (Predicted: Pig, Cynomolgus monkey)

预测的种属支持售后

验证应用

IHC-Fr

分子量

Predicted band size: 17 kDa

阳性对照

Mouse cerebellum tissue.

偶联

unconjugated

克隆号

JM36-62

产品特性

形态

Liquid

浓度

1ug/ul

存放说明

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

存储缓冲液

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

纯化方式

Protein A affinity purified.

应用稀释度

  • IHC-Fr

  • 1:500

靶点

功能

Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).

背景文献

1. Hennessy E et al. Systemic TNF-a produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration. Brain Behav Immun 59:233-244 (2017).

2. Arentsen T et al. The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Mol Psychiatry 22:257-266 (2017).

亚细胞定位

Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, Cell projection, phagocytic cup.

UNIPROT #

SwissProt: P55008 Human

SwissProt: O70200 Mouse

SwissProt: P55009 Rat

别名

AIF 1 antibody

AIF-1 antibody

Aif1 antibody

AIF1 protein antibody

AIF1_HUMAN antibody

Allograft inflammatory factor 1 antibody

Allograft inflammatory factor 1 splice variant G antibody

allograft inflammatory factor-1 splice variant Hara-1 antibody

balloon angioplasty responsive transcription antibody

BART 1 antibody

展开

图片

  • Application: IHC-Fr<br /><br />Species: Mouse<br /><br />Site: Cerebellum<br /><br />Sample: Frozen section<br /><br />Antibody concentration: 1: 500 (Iba1, <a href="/products/HA601376" style="font-weight: bold;text-decoration: underline;">HA601376</a>, green); 1:500 (MAG, <a href="/products/HA721818" style="font-weight: bold;text-decoration: underline;">HA721818</a>, red)<br /><br />Antigen retrieval: Not required

    Application: IHC-Fr

    Species: Mouse

    Site: Cerebellum

    Sample: Frozen section

    Antibody concentration: 1: 500 (Iba1, HA601376, green); 1:500 (MAG, HA721818, red)

    Antigen retrieval: Not required

  • Application: IHC-Fr<br /><br />Species: Mouse<br /><br />Site: Cerebellum<br /><br />Sample: Frozen section<br /><br />Antibody concentration: 1: 500 (Iba1, <a href="/products/HA601376" style="font-weight: bold;text-decoration: underline;">HA601376</a>, green); 1:500 (PSD95, <a href="/products/ET1602-20" style="font-weight: bold;text-decoration: underline;">ET1602-20</a>, red)<br /><br />Antigen retrieval: Not required

    Application: IHC-Fr

    Species: Mouse

    Site: Cerebellum

    Sample: Frozen section

    Antibody concentration: 1: 500 (Iba1, HA601376, green); 1:500 (PSD95, ET1602-20, red)

    Antigen retrieval: Not required

  • Application: IHC-Fr<br /><br />Species: Mouse<br /><br />Site: Spleen<br /><br />Sample: Frozen section<br /><br />Antibody concentration: 1: 500 (Iba1, <a href="/products/HA601376" style="font-weight: bold;text-decoration: underline;">HA601376</a>, green); 1:1,000 (F4/80, <a href="/products/HA721520" style="font-weight: bold;text-decoration: underline;">HA721520</a>, red)<br /><br />Antigen retrieval: Not required

    Application: IHC-Fr

    Species: Mouse

    Site: Spleen

    Sample: Frozen section

    Antibody concentration: 1: 500 (Iba1, HA601376, green); 1:1,000 (F4/80, HA721520, red)

    Antigen retrieval: Not required

  • Application: IHC-Fr<br /><br />Species: Rat<br /><br />Site: Spleen<br /><br />Sample: Frozen section<br /><br />Antibody concentration: 1: 500 (Iba1, <a href="/products/HA601376" style="font-weight: bold;text-decoration: underline;">HA601376</a>, green); 1:1,000 (F4/80, <a href="/products/HA721520" style="font-weight: bold;text-decoration: underline;">HA721520</a>, red)<br /><br />Antigen retrieval: Not required

    Application: IHC-Fr

    Species: Rat

    Site: Spleen

    Sample: Frozen section

    Antibody concentration: 1: 500 (Iba1, HA601376, green); 1:1,000 (F4/80, HA721520, red)

    Antigen retrieval: Not required

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

同靶点&同通路的产品

metafield image

Iba1 Rabbit Polyclonal Antibody

Application: IHC-P

Reactivity: Human,Mouse

Conjugate: unconjugated

metafield image

iFluor™ 488 Conjugated Iba1 Recombinant Rabbit Monoclonal Antibody [JM36-62]

Application: IF-Cell,FC

Reactivity: Human,Mouse,Rat

Conjugate: iFluor™ 488

metafield image

Iba1 Recombinant Mouse Monoclonal Antibody [8G8]

Application: WB,IHC-P,FC,IP,IHC-Fr,IF-Cell

Reactivity: Human,Mouse,Rat,Cynomolgus monkey,Pig

Conjugate: unconjugated

metafield image

Iba1 Recombinant Rabbit Monoclonal Antibody [JM36-62]

Application: WB,IHC-P,IHC-Fr,IF-Tissue,IF-Cell,FC,IP,mIHC

Reactivity: Human,Mouse,Rat,Cynomolgus monkey,Pig

Conjugate: unconjugated

metafield image

Iba1 Recombinant Antibody [JM36-62] - Rat IgG1 (Chimeric)

Application: IHC-Fr,IHC-P

Reactivity: Mouse,Rat,Cynomolgus monkey,Pig

Conjugate: unconjugated

metafield image

Iba1 Recombinant Antibody [JM36-62] - Guinea pig IgG2 (Chimeric)

Application: IHC-Fr,WB

Reactivity: Human,Mouse,Rat,Cynomolgus monkey,Pig

Conjugate: unconjugated