FOXP3 Recombinant Rabbit Monoclonal Antibody
Rmb: 1500
Catalog# IRS008
FOXP3 Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
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unconjugated
概述
产品名称
FOXP3 Recombinant Rabbit Monoclonal Antibody
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within human FOXP3 aa 101-370.
种属反应性
Human
验证应用
mIHC
靶点分子量
Predicted band size: 47 kDa
阳性对照
Human lung cancer tissue, human tonsil tissue, human lung squamous cell carcinoma tissue.
偶联
unconjugated
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
mIHC
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1:100
靶点
功能
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
背景文献
1. Wang J et al. Human FOXP3 and tumour microenvironment. Immunology. 2023 Feb
2. Ziółkowska-Suchanek I et al. FOXP3: A Player of Immunogenetic Architecture in Lung Cancer. Genes (Basel). 2024 Apr
亚细胞定位
Nucleus, Cytoplasm.
UNIPROT
别名
AIID antibody
DIETER antibody
Forkhead box P3 antibody
Forkhead box protein P3 antibody
FOXP3 antibody
FOXP3_HUMAN antibody
FOXP3delta7 antibody
Immune dysregulation polyendocrinopathy enteropathy X linked antibody
Immunodeficiency polyendocrinopathy enteropathy X linked antibody
IPEX antibody
展开图片
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mIHC analysis of human lung cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with FOXP3 (IRS008), CD57 (IRS027), MPO (IRS037), CD8 (IRS007) and panCK (IRS010) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-FOXP3 antibody (IRS008) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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mIHC analysis of human lung squamous cell carcinoma tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-FOXP3 antibody (IRS008) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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