FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]
Catalog# IRS008
FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]
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mIHC
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Human
概述
产品名称
FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within human FOXP3 aa 101-370.
种属反应性
Human
验证应用
mIHC
分子量
Predicted band size: 47 kDa
偶联
unconjugated
克隆号
PSH07-47
产品特性
形态
Liquid
浓度
1ug/ul
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
mIHC
-
1:100
靶点
功能
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
背景文献
1. Wang J et al. Human FOXP3 and tumour microenvironment. Immunology. 2023 Feb
2. Ziółkowska-Suchanek I et al. FOXP3: A Player of Immunogenetic Architecture in Lung Cancer. Genes (Basel). 2024 Apr
亚细胞定位
Nucleus, Cytoplasm.
UNIPROT #
别名
AIID antibody
DIETER antibody
Forkhead box P3 antibody
Forkhead box protein P3 antibody
FOXP3 antibody
FOXP3_HUMAN antibody
FOXP3delta7 antibody
Immune dysregulation polyendocrinopathy enteropathy X linked antibody
Immunodeficiency polyendocrinopathy enteropathy X linked antibody
IPEX antibody
展开图片
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mIHC analysis of human lung cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with FOXP3 (IRS008), CD57 (IRS027), MPO (IRS037), CD8 (IRS007) and panCK (IRS010) antibody at 1/100 dilution. The immunostaining was performed with the IRISKit® HyperView mTSA Kit (MH900206). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"