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FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]

RMB: 1500

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Catalog# IRS008

FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]

Application

  • mIHC

Reactivity

  • Human

概述

产品名称

FOXP3 Recombinant Rabbit Monoclonal Antibody [PSH07-47]

抗体类型

Recombinant Rabbit monoclonal Antibody

免疫原

Recombinant protein within human FOXP3 aa 101-370.

种属反应性

Human

验证应用

mIHC

分子量

Predicted band size: 47 kDa

偶联

unconjugated

克隆号

PSH07-47

产品特性

形态

Liquid

浓度

1ug/ul

存放说明

Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

存储缓冲液

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

亚型

IgG

纯化方式

Protein A affinity purified.

应用稀释度

  • mIHC

  • 1:100

靶点

功能

FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.

背景文献

1. Wang J et al. Human FOXP3 and tumour microenvironment. Immunology. 2023 Feb

2. Ziółkowska-Suchanek I et al. FOXP3: A Player of Immunogenetic Architecture in Lung Cancer. Genes (Basel). 2024 Apr

亚细胞定位

Nucleus, Cytoplasm.

UNIPROT #

SwissProt: Q9BZS1 Human

别名

AIID antibody

DIETER antibody

Forkhead box P3 antibody

Forkhead box protein P3 antibody

FOXP3 antibody

FOXP3_HUMAN antibody

FOXP3delta7 antibody

Immune dysregulation polyendocrinopathy enteropathy X linked antibody

Immunodeficiency polyendocrinopathy enteropathy X linked antibody

IPEX antibody

展开

图片

  • mIHC analysis of human lung cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with FOXP3 (<a href="/products/IRS008" style="font-weight: bold;text-decoration: underline;">IRS008</a>), CD57 (<a href="/products/IRS027" style="font-weight: bold;text-decoration: underline;">IRS027</a>), MPO (<a href="/products/IRS037" style="font-weight: bold;text-decoration: underline;">IRS037</a>), CD8 (IRS007) and panCK (<a href="/products/IRS010" style="font-weight: bold;text-decoration: underline;">IRS010</a>) antibody at 1/100 dilution. The immunostaining was performed with the IRISKit&reg; HyperView mTSA Kit (<a href="/products/MH900206" style="font-weight: bold;text-decoration: underline;">MH900206</a>). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

    mIHC analysis of human lung cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with FOXP3 (IRS008), CD57 (IRS027), MPO (IRS037), CD8 (IRS007) and panCK (IRS010) antibody at 1/100 dilution. The immunostaining was performed with the IRISKit® HyperView mTSA Kit (MH900206). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"