PE Conjugated Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
Catalog# HA600123F
PE Conjugated Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
-
FC
-
Human
-
PE
概述
产品名称
PE Conjugated Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
抗体类型
Recombinant Mouse Monoclonal Antibody
免疫原
Recombinant protein within Human CD8a aa 22-182.
种属反应性
Human
验证应用
FC
分子量
Predicted band size: 26 kDa
阳性对照
Human peripheral blood lymphocytes.
偶联
PE
克隆号
PSH04-94
反应性数据
| FC | |
|---|---|
| Human |
|
产品特性
形态
Liquid
存放说明
Store at 2℃ to 8℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
FC
-
5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
靶点
功能
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.
背景文献
1. Zheng Z et al. CD8A as a Prognostic and Immunotherapy Predictive Biomarker Can Be Evaluated by MRI Radiomics Features in Bladder Cancer. Cancers (Basel). 2022 Oct
2. Tanemoto S et al. Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4(+)CD8A(+) T cells related to mouse CD4 cytotoxic T cells. Front Immunol. 2022 Oct
亚细胞定位
Cell membrane; Secreted.
UNIPROT
别名
alpha polypeptide (p32) antibody
CD_antigen=CD8a antibody
CD8 antibody
CD8 antigen alpha polypeptide antibody
CD8 antigen alpha polypeptide (p32) antibody
CD8 antigen, alpha polypeptide (p32) antibody
CD8a antibody
CD8A antigen antibody
CD8A molecule antibody
CD8A_HUMAN antibody
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