Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
Catalog# HA601339
Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
-
FC
-
Human
-
unconjugated
概述
产品名称
Human CD8 alpha Recombinant Mouse Monoclonal Antibody [PSH04-94]
抗体类型
Recombinant Mouse Monoclonal Antibody
免疫原
Recombinant protein within Human CD8a aa 22-182.
种属反应性
Human
验证应用
FC
分子量
Predicted band size: 26 kDa
阳性对照
Human peripheral blood lymphocytes.
偶联
unconjugated
克隆号
PSH04-94
反应性数据
| FC | |
|---|---|
| Human |
|
产品特性
形态
Liquid
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
PBS (pH7.4).
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
FC
-
1:1,000
靶点
功能
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.
背景文献
1. Zheng Z et al. CD8A as a Prognostic and Immunotherapy Predictive Biomarker Can Be Evaluated by MRI Radiomics Features in Bladder Cancer. Cancers (Basel). 2022 Oct
2. Tanemoto S et al. Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4(+)CD8A(+) T cells related to mouse CD4 cytotoxic T cells. Front Immunol. 2022 Oct
亚细胞定位
Cell membrane; Secreted.
UNIPROT
别名
alpha polypeptide (p32) antibody
CD_antigen=CD8a antibody
CD8 antibody
CD8 antigen alpha polypeptide antibody
CD8 antigen alpha polypeptide (p32) antibody
CD8 antigen, alpha polypeptide (p32) antibody
CD8a antibody
CD8A antigen antibody
CD8A molecule antibody
CD8A_HUMAN antibody
展开图片
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Flow cytometric analysis of human peripheral blood lymphocytes labeling Human CD8 alpha.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601339, 1μg/mL) (red). After incubation of the primary antibody at +4℃ for 30 minutes, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1125) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; blue).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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