GSK3 alpha Rabbit Polyclonal Antibody

功能

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. GSK3 alpha requires primed phosphorylation of the majority of its substrates. It contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. GSK3 alpha regulates glycogen metabolism in liver, but not in muscle. It may also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, GSK3 alpha regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin.

背景文献

1. Glycogen synthase kinase-3: properties, functions, and regulation." Ali A., Hoeflich K.P., Woodgett J.R. Chem. Rev. 101:2527-2540(2001)

2. "GSK-3alpha regulates production of Alzheimer\'s disease amyloid-beta peptides." Phiel C.J., Wilson C.A., Lee V.M., Klein P.S. Nature 423:435-439(2003)

3. "GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt." Asuni A.A., Hooper C., Reynolds C.H., Lovestone S., Anderton B.H., Killick R. Eur. J. Neurosci. 24:3387-3392(2006) "Glycogen synthase kinase 3: more than a namesake." Rayasam G.V., Tulasi V.K., Sodhi R., Davis J.A., Ray A. Br. J. Pharmacol. 156:885-898(2009)

序列相似性

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

翻译后修饰

Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.

亚细胞定位

Cytoplasm, Nucleus, Apical dendrite, Mitochondrion.

UNIPROT

SwissProt: P49840 Human

别名

DKFZp686D0638 antibody

Glycogen synthase kinase 3 alpha antibody

Glycogen synthase kinase-3 alpha antibody

GSK 3 alpha antibody

GSK 3A antibody

GSK-3 alpha antibody

Gsk3a antibody

GSK3A_HUMAN antibody

GSK3alpha antibody

Serine/threonine protein kinase GSK3A antibody