E-Cadherin Recombinant Mouse Monoclonal Antibody
Catalog# IRS031
E-Cadherin Recombinant Mouse Monoclonal Antibody
-
mIHC
-
Human
概述
产品名称
E-Cadherin Recombinant Mouse Monoclonal Antibody
抗体类型
Recombinant Mouse Monoclonal Antibody
免疫原
Recombinant protein within mouse E-Cadherin aa 350-550.
种属反应性
Human
验证应用
mIHC
分子量
Predicted band size: 98 kDa
阳性对照
Human pancreas tissue.
偶联
unconjugated
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
mIHC
-
1:100
靶点
功能
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
背景文献
1. Thomas E Meigs et al. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem 277(27):24594-600 (2002)
2. Georgia Agiostratidou et al. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. 96(4):1182-8 (2006)
亚细胞定位
Cell membrane, Endosome, Golgi apparatus.
UNIPROT
别名
Cadherin-1
CAM 120/80
Epithelial cadherin (E-cadherin)
Uvomorulin
图片
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mIHC analysis of human pancreas tissue (Formalin/PFA-fixed paraffin-embedded sections) with Mouse anti-E-Cadherin antibody (IRS031) at 1/100 dilution. The immunostaining was performed with the IRISKit® HyperView mTSA Kit (MH900206). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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