Human FGF-21, C-His Tag Protein

RMB: 599 特惠 1619 1619

产品规格

20μg

50μg

100μg

现在订购，【现货】

点击询价

联系我们

邮箱: sales@huabio.cn

电话: 0571-88062880

查找各地代理商

Catalog# HA210921

Human FGF-21, C-His Tag Protein

Product Information

Product name

Human FGF-21, C-His Tag Protein

Catalog No.

HA210921

Predicted molecular mass

20.8 kD

Protein construction description

A DNA sequence encoding the human FGF-21 protein (Q9NSA1) (His 29-Ser 209) was expressed with a His tag at the C-terminus

Accession

Q9NSA1

Protein construction

FGF-21 (29-209) His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the co-receptors FGF receptor 1 and β-Klotho. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGFs act through a family of four FGF receptors. Binding is complicated and requires both interaction of the FGF molecule with an FGF receptor and binding to heparin through a heparin binding domain. Endocrine FGFs lack a heparin binding domain and thus can be released into the circulation. FGF21 is a hepatokine – i.e., a hormone secreted by the liver – that regulates simple sugar intake and preferences for sweet foods via signaling through FGF21 receptors in the paraventricular nucleus of the hypothalamus and correlates with reduced dopamine neurotransmission within the nucleus accumbens. A single-nucleotide polymorphism of the FGF21 gene – the FGF21 rs838133 variant (frequency 44.7%) – has been identified as a genetic mechanism responsible for the sweet tooth behavioral phenotype, a trait associated with cravings for sweets and high sugar consumption, in both humans and mice.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Human FGF-21, C-His Tag Protein

RMB: 599 特惠 1619 1619

产品规格

联系我们

Product Information

Product name

Catalog No.

Predicted molecular mass

Protein construction description

Accession

Protein construction

Source

Bio Activity

Purity

Endotoxin

Formulation

Species

Background

Usage guide

Shipping

Storage

Reconstitution

同靶点&同通路的产品

Human SCF/KITLG, C-His Tag (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human IFN-alpha/beta R1, C-His (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human HGF, C-Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-7, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human EIF4B, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human Erythropoietin/EPO, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human VEGF-C, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human Angiopoietin-1/ANGPT1, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human M-CSF/CSF1 (33-255), C His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human M-CSF/CSF1 (33-190), Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-3, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human Caspase-9/CASP9, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IFN-alpha/beta R2, C-His Tag (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human FGF-4, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human VEGF165, Tag Free Protein