CD130 / GP130 Recombinant Rabbit Monoclonal Antibody [PSH20-62] - BSA and Azide free
Catalog# HA751763
CD130 / GP130 Recombinant Rabbit Monoclonal Antibody [PSH20-62] - BSA and Azide free
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IHC-Fr
-
FC
-
Mouse
-
HA724164
含抗保成分
-
unconjugated
概述
产品名称
CD130 / GP130 Recombinant Rabbit Monoclonal Antibody [PSH20-62] - BSA and Azide free
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within mouse CD130 / GP130 aa 1-617.
种属反应性
Mouse
验证应用
IHC-Fr, FC
分子量
Predicted band size: 102 kDa
阳性对照
Mouse spleen, C57BL/6 mouse splenocytes.
偶联
unconjugated
克隆号
PSH20-62
产品特性
形态
Liquid
浓度
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
1*PBS (pH7.4).
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
IHC-Fr
-
1:500
-
FC
-
1:1,000
靶点
功能
Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
背景文献
1. Zanders L et al. Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting. J Cachexia Sarcopenia Muscle. 2022 Feb
2. Zhu X et al. Intermittent Fasting-Induced Orm2 Promotes Adipose Browning via the GP130/IL23R-p38 Cascade. Adv Sci (Weinh). 2024 Nov
亚细胞定位
Cell membrane.
UNIPROT
别名
CD130 antibody
CD130 antigen antibody
CDw130 antibody
gp130 antibody
GP130 RAPS antibody
IL 6R beta antibody
IL-6 receptor subunit beta antibody
IL-6R subunit beta antibody
IL-6R-beta antibody
IL-6RB antibody
展开图片
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Application: IHC-Fr
Species: Mouse
Site: spleen
Sample: Frozen section
Antibody concentration: 1/500
Antigen retrieval: Not required -
Flow cytometric analysis of C57BL/6 mouse splenocytes labeling CD130 / GP130 (HA751763) and CD3 (HA600118F, APC).
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA751763, 1/1,000). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Rabbit IgG Secondary antibody (HA1121) at 1/1,000 dilution for 30 minutes at +4℃. Compared with Rabbit IgG Isotype Control (iFluor™ 488, 1/1,000).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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