CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33]
Rmb: 699 特惠 1500
Catalog# HA724144
CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33]
-
WB
-
Mouse
-
HA751749
不含抗保成分
-
unconjugated
概述
产品名称
CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33]
抗体类型
Recombinant Rabbit monoclonal Antibody
种属反应性
Mouse
验证应用
WB
靶点分子量
Predicted band size: 34 kDa
阳性对照
Mouse spleen tissue lysate, Mouse small intestine tissue lysate.
偶联
unconjugated
克隆号
PSH20-33
反应性数据
| WB | |
|---|---|
| Mouse |
|
| Human |
|
| Rat |
|
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
存储缓冲液
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:5,000
靶点
功能
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
背景文献
1. Yang Q et al. NADase CD38 is a key determinant of ovarian aging. Nat Aging. 2024 Jan
2. Yu S et al. CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice. Aging Cell. 2025 Sep
亚细胞定位
Cell surface, Membrane.
UNIPROT
别名
Acute lymphoblastic leukemia cells antigen CD38 antibody
ADP ribosyl cyclase 1 antibody
ADP ribosyl cyclase antibody
ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody
ADP-ribosyl cyclase 1 antibody
ADPRC 1 antibody
ADPRC1 antibody
cADPr hydrolase 1 antibody
CD 38 antibody
CD38 antibody
展开图片
-
Western blot analysis of CD38 on different lysates with Rabbit anti-CD38 antibody (HA724144) at 1/5,000 dilution.
Lane 1: Mouse spleen tissue lysate
Lane 2: Mouse small intestine tissue lysate
Lysates/proteins at 40 µg/Lane.
Predicted band size: 34 kDa
Observed band size: 45 kDa
Exposure time: 10 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA724144) at 1/5,000 dilution was used in primary antibody dilution (K1803) at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
浙公网安备 33019202000643号