Glucagon Recombinant Rabbit Monoclonal Antibody
Catalog# IRS150RB
Glucagon Recombinant Rabbit Monoclonal Antibody
-
mIHC
-
Human
-
unconjugated
概述
产品名称
Glucagon Recombinant Rabbit Monoclonal Antibody
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide within human Glucagon aa 40-90.
种属反应性
Human
验证应用
mIHC
分子量
Predicted band size: 21 kDa
阳性对照
Rat pancreas tissue, mouse pancreas tissue, human pancreas tissue.
偶联
unconjugated
产品特性
形态
Liquid
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
mIHC
-
1:100
靶点
功能
Glucagon is a pancreatic hormone that functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone.
背景文献
1. Gao Z et al. Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1. J Endocrinol 230:347-55 (2016).
2. Long AJ et al. Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas. Toxicol Pathol 44:998-1012 (2016).
亚细胞定位
Secreted.
UNIPROT
别名
GCG antibody
glucagon
图片
-
mIHC analysis of human pancreas tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-Glucagon antibody (IRS150RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
