iFluor™ 555 Conjugated EpCAM Recombinant Rabbit Monoclonal Antibody [PS01-69]
Catalog# HA720218F
iFluor™ 555 Conjugated EpCAM Recombinant Rabbit Monoclonal Antibody [PS01-69]
-
FC
-
Human
-
iFluor™ 555
概述
产品名称
iFluor™ 555 Conjugated EpCAM Recombinant Rabbit Monoclonal Antibody [PS01-69]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide.
种属反应性
Human
验证应用
FC
分子量
Predicted band size: 35 kDa
阳性对照
HT-29.
偶联
iFluor™ 555
克隆号
PS01-69
反应性数据
| FC | |
|---|---|
| Human |
|
产品特性
形态
Liquid
浓度
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
FC
-
1:1,000
靶点
功能
EPCAM is a carcinoma-associated antigen and belongs to a family which includes at least 2 type I membrane proteins. The EPCAM protein has a role in embryonic stem cells proliferation and differentiation. EPCAM is used as a target for immunotherapy treatment of human carcinomas. EPCAM is expressed on most normal epithelial cells and gastrointestinal carcinomas and acts as a homotypic calcium-independent cell adhesion molecule. Epithelial cell adhesion molecules (EPCAM) can act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for supplying immunological barrier as a first line of defense against mucosal infection. EPCAM gene mutations result in congenital tufting enteropathy.
背景文献
1. Li D et al. EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors. Sci Adv. 2023 Dec
2. Li F et al. EpCAM-Targeting Aptamer Radiotracer for Tumor-Specific PET Imaging. Bioconjug Chem. 2021 Jun
亚细胞定位
Lateral cell membrane, Cell junction.
UNIPROT
别名
17 1A antibody
323/A3 antibody
Adenocarcinoma associated antigen antibody
Adenocarcinoma-associated antigen antibody
Antigen identified by monoclonal antibody
AUA1 antibody
AUA1 antibody
CD326 antibody
CD326 antigen antibody
Cell surface glycoprotein Trop 1 antibody
展开图片
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Flow cytometric analysis of HT-29 cells labeling EpCAM.
Cells were washed twice with cold PBS and resuspend. Then incubated for 1 hour at +4℃ with EpCAM (HA720218F, red, 1/1,000) and Rabbit IgG Isotype Control (iFluor™ 555, green, 1/1,000). Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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