TNIP2 Rabbit Polyclonal Antibody
Rmb: 1500
Catalog# ER1917-94
TNIP2 Rabbit Polyclonal Antibody
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WB
-
IHC-P
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IF-Tissue
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Human
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Rat
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unconjugated
概述
产品名称
TNIP2 Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
免疫原
KLH conjugated synthetic peptide derived from human TNIP2/ABIN2/TNFAIP3 interacting protein 2
种属反应性
Human, Rat
验证应用
WB, IHC-P, IF-Tissue
靶点分子量
49 kDa
阳性对照
Ubiquitously expressed in all tissues examined.
偶联
unconjugated
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
存储缓冲液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:500-2000
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IHC-P
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1:100-500
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IF-tissue
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1:100-500
靶点
功能
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
背景文献
暂无
UNIPROT
别名
A20 binding inhibitor of NF kappaB activation 2 antibody
A20-binding inhibitor of NF-kappa-B activation 2 antibody
ABIN 2 antibody
ABIN-2 antibody
Fetal liver LKB1-interacting protein antibody
FLIP1 antibody
KLIP antibody
LKB1 interacting protein antibody
TNFAIP3 interacting protein 2 antibody
TNFAIP3-interacting protein 2 antibody
展开图片
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Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TNIP2 Polyclonal Antibody, Unconjugated(ER1917-94) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining -
Sample: A431 Cell (Human) Lysate at 40 ug
Primary: Anti-TNIP2 (ER1917-94) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
Predicted band size: 49 kD
Observed band size: 49 kD
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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