CD11b Mouse Monoclonal Antibody [4G2]
Catalog# RT1107
CD11b Mouse Monoclonal Antibody [4G2]
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WB
-
IP
-
IF
-
FC
-
Human
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Mouse
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unconjugated
概述
产品名称
CD11b Mouse Monoclonal Antibody [4G2]
抗体类型
Mouse Monoclonal Antibody
免疫原
peptide
种属反应性
Human, Mouse
验证应用
WB, IP, IF, FC
分子量
170kDa
阳性对照
PBL, RAW 264.7.
偶联
unconjugated
克隆号
4G2
产品特性
形态
Liquid
浓度
存放说明
Store at +4℃
存储缓冲液
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
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WB
-
1:500
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IP
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1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
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IF
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1:50-500
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FC
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1 μg per 1 x 106 cells
靶点
功能
Integrin ?M, also designated complement component receptor-3 ?, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin ?M combines with the Integrin ∫2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin ?M/∫2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
背景文献
1. Nueda, A., et al. 1995. Hematopoietic cell-type-dependent regulation of leukocyte integrin functional activity: CD11b and CD11c expression inhibits LFA-1-dependent aggregation of differentiatied U937 cells. Cell. Immunol. 164: 163-169.
2. Li, R., et al. 1995. A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte Integrins CD11b/CD18 and CD11c/CD18. J. Cell Biol. 129: 1143-115
亚细胞定位
Membrane
UNIPROT
别名
antigen CD11b (p170) antibody
Antigen CD11b p170 antibody
CD11 antigen like family member B antibody
CD11 antigen-like family member B antibody
CD11b antibody
CD11b/CD18 antibody
CD49d antibody
Cell surface glycoprotein MAC-1 subunit alpha antibody
Complement component 3 receptor 3 subunit antibody
Complement Component Receptor 3 Alpha antibody
展开图片
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Western blot analysis of Integrin αM expression in human PBL whole cell lysate immunoprecipitated with Integrin αM (2LPM19c) and detected with Integrin αM (H-61).
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Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing membrane staining.
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FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.
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FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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