WWOX Recombinant Rabbit Monoclonal Antibody [PSH15-44]

功能

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. WWOX is also known as human accelerated region 6. It may, therefore, have played a key role in differentiating humans from apes.

背景文献

1. Hsu CY et al. WWOX and Its Binding Proteins in Neurodegeneration. Cells. 2021 Jul

2. Baryła I et al. WWOX and metabolic regulation in normal and pathological conditions. J Mol Med (Berl). 2022 Dec

亚细胞定位

Cytoplasm, Nucleus, Mitochondrion, Golgi apparatus, Lysosome.

UNIPROT

SwissProt: Q9NZC7 Human

SwissProt: Q91WL8 Mouse

Entrez Gene: 292041 Rat

别名