Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]
Rmb: 666 特惠 1500
Catalog# HA722865
Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]
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IHC-P
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Human
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unconjugated
概述
产品名称
Placental lactogen Recombinant Rabbit Monoclonal Antibody [JE60-49]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide within human Placental lactogen aa 101-150 / 217.
种属反应性
Human
验证应用
IHC-P
靶点分子量
Predicted band size: 25 kDa
阳性对照
Human placenta tissue.
偶联
unconjugated
克隆号
JE60-49
反应性数据
已验证（内部验证通过）
文献已报道（未内部验证，但有文献支持）
预测可反应（基于高同源性）
不推荐（内部验证未通过）
| WB | IHC-P | |
|---|---|---|
| human |
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|
| mouse |
|
|
| rat |
|
|
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
存储缓冲液
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
IHC-P
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1:1,000
靶点
功能
Placental lactogen, also called chorionic somatomammotropin, is a polypeptide placental hormone, part of the somatotropin family. Its structure and function is similar to that of growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. These hormones can contribute to lactogenesis, luteal maintenance and progesterone production (in rats) during the later stages of gestation. Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism.
背景文献
1. Cattini PA, Jin Y, Jarmasz JS, Noorjahan N, Bock ME. Obesity and regulation of human placental lactogen production in pregnancy. J Neuroendocrinol. 2020 Nov;32(11):e12859. doi: 10.1111/jne.12859. Epub 2020 Jun 5. PMID: 32500948.
2. Walker WH, Fitzpatrick SL, Barrera-Saldaña HA, Resendez-Perez D, Saunders GF. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Endocr Rev. 1991 Nov;12(4):316-28. doi: 10.1210/edrv-12-4-316. PMID: 1760991.
亚细胞定位
Secreted.
别名
Choriomammotropin antibody
Chorionic somatomammotropin A antibody
chorionic somatomammotropin B antibody
chorionic somatomammotropin hormone 1 (placental lactogen) antibody
Chorionic somatomammotropin hormone 1 antibody
chorionic somatomammotropin hormone 2 antibody
Chorionic somatomammotropin hormone antibody
CS 2 antibody
CS-2 antibody
CS1 antibody
展开图片
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Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-Placental lactogen antibody (HA722865) at 1/1,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA722865) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
☑ Relative expression (RE)
Immunohistochemical analysis of paraffin-embedded human kidney tissue (negative) with Rabbit anti-Placental lactogen antibody (HA722865) at 1/1,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA722865) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
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