Paxillin Rabbit Polyclonal Antibody

功能

Paxillin is a focal adhesion phosphoprotein that is localized to the cytoskeleton. Phosphorylation of paxillin has been shown to occur in response to PDGF treatment, v-src transformation or cross-linking of integrins. FAK (focal adhesion kinase) and PYK2 have been shown to phosphorylate paxillin. FAK phosphorylates paxillin specifically on Tyr-118 in vitro. However, FAK phosphorylation does not seem to be required for the recruitment of paxillin to cell adhesion sites. Paxillin may play a role in signal transduction, regulation of cell morphology and the recruitment of structural and signaling molecules to focal adhesions. It has been shown that the amount of paxillin is reduced in mitotic cells by proteolytic downregulation and that paxillin is alternatively phosphorylated on serine rather than on tyrosine and serine during mitosis.

背景文献

1. Huck, B., et al. 2012. GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. J. Biol. Chem. 287: 34604-34613.

2. Heering, J., et al. 2012. Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer. Cancer Res. 72: 2855-2866.

亚细胞定位

Cytoplasm, Cell junction

UNIPROT

SwissProt: P49023 Human

别名

FLJ16691 antibody

FLJ23042 antibody

Paired box protein Pax 1 antibody

PAX 1 antibody

PAX1 antibody

PAXI_HUMAN antibody

Paxillin alpha antibody

Paxillin antibody

PXN antibody

PXN protein antibody