PSD95 Rabbit Polyclonal Antibody

功能

PSD-95 is a member of the membrane-associated guanylate kinase(MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the?clustering of receptors, ion channels, and associated signaling proteins.PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density ofneurons,and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin,NMDA receptors,AMPA receptors, and potassium channels.It plays an important role in synaptic plasticity and the stabilization of synaptic changes during?long-term potentiation.

背景文献

1. "Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues." Stathakis D.G.,Hoover K.B.,You Z.,Bryant P.J.Genomics 44:71-82(1997)

2. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis." Lee H.W.,Choi J.,Shin H.,Kim K.,Yang J.,Na M.,Choi S.Y.,Kang G.B.,Eom S.H.,Kim H.,Kim E. J. Neurosci. 28:14546-14556(2008)

序列相似性

Belongs to the MAGUK family.

组织特异性

Brain.

翻译后修饰

Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).; Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.

亚细胞定位

Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse.

UNIPROT

SwissProt: P78352 Human

别名