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PERK Rabbit Polyclonal Antibody

RMB: 1500

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Catalog# ER64553

PERK Rabbit Polyclonal Antibody

Application

  • IF-Cell

  • WB

  • IHC-P

  • IF-Tissue

Reactivity

  • Human

  • Mouse

  • Rat

Conjugation

  • unconjugated

This product has been cited in peer reviewed publications, see list HERE

概述

产品名称

PERK Rabbit Polyclonal Antibody

抗体类型

Rabbit Polyclonal Antibody

免疫原

The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range:947-996

种属反应性

Human, Mouse, Rat

验证应用

IF-Cell, WB, IHC-P, IF-Tissue

分子量

125 kDa

阳性对照

MCF-7 cell, human colon carcinoma, rat-spleen.

偶联

unconjugated

产品特性

形态

Liquid

存放说明

Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

亚型

IgG

纯化方式

Immunogen affinity purified.

应用稀释度

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:100-1:300

  • IF-Tissue

  • 1:50-1:200

靶点

功能

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

背景文献

暂无

亚细胞定位

Endoplasmic reticulum membrane.

UNIPROT

SwissProt: Q9NZJ5 Human

别名

DKFZp781H1925 antibody

E2AK3_HUMAN antibody

EC 2.7.11.1 antibody

Eif2ak3 antibody

Eukaryotic translation initiation factor 2 alpha kinase 3 antibody

Eukaryotic translation initiation factor 2-alpha kinase 3 antibody

Heme regulated EIF2 alpha kinase antibody

HRI antibody

HsPEK antibody

Pancreatic eIF2 alpha kinase antibody

展开

图片

  • Western blot analysis of lysates from MCF-7 cells, using PEK/PERK Antibody. The lane on the right is blocked with the synthesized peptide.

    Western blot analysis of lysates from MCF-7 cells, using PEK/PERK Antibody. The lane on the right is blocked with the synthesized peptide.

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using PEK/PERK Antibody. The picture on the right is blocked with the synthesized peptide.

    Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using PEK/PERK Antibody. The picture on the right is blocked with the synthesized peptide.

  • Immunofluorescence analysis of rat-spleen tissue. 1,PERK Polyclonal Antibody(red) was diluted at 1:200(4℃,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

    Immunofluorescence analysis of rat-spleen tissue. 1,PERK Polyclonal Antibody(red) was diluted at 1:200(4℃,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

引文

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