iFluor™ 488 Conjugated Lamin B1 Recombinant Rabbit Monoclonal Antibody [SI17-07]

功能

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.

背景文献

1. Cruz OH et al. Multinucleation and Polykaryon Formation is Promoted by the EhPC4 Transcription Factor in Entamoeba histolytica. Sci Rep 6:19611 (2016).

2. Lund K et al. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS One 10:e0123684 (2015).

序列相似性

Belongs to the intermediate filament family.

翻译后修饰

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

亚细胞定位

Nucleus inner membrane.

UNIPROT

SwissProt: P20700 Human

SwissProt: P14733 Mouse

SwissProt: P70615 Rat

别名

ADLD antibody

lamin B1 antibody

Lamin-B1 antibody

LMN antibody

LMN2 antibody

LMNB antibody

Lmnb1 antibody

LMNB1_HUMAN antibody

MGC111419 antibody

OTTHUMP00000159218 antibody