S100A8+S100A9 Recombinant Rabbit Multiclonal Antibody
Catalog# IRS196RB
S100A8+S100A9 Recombinant Rabbit Multiclonal Antibody
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mIHC
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Mouse
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unconjugated
概述
产品名称
S100A8+S100A9 Recombinant Rabbit Multiclonal Antibody
抗体类型
Recombinant Rabbit multiclonal
种属反应性
Mouse
验证应用
mIHC
分子量
Predicted band size: 11/13 kDa
阳性对照
Mouse spleen tissue.
偶联
unconjugated
产品特性
形态
Liquid
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
mIHC
-
1:100
靶点
功能
S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.[5] It is also known as calgranulin A. S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. The proteins S100A8 and S100A9 form a heterodimer called calprotectin. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis [5] and post COVID-19 condition.
背景文献
1. Wang Q et al. S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury. Biomed Pharmacother. 2023 Dec
2. Wang Y et al. S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis. Cell Death Dis. 2024 Jun
亚细胞定位
Secreted, Cytoplasm, cytoskeleton, Cell membrane
别名
Calgranulin-A antibody
Calprotectin L1L subunit antibody
CFAG antibody
Cystic fibrosis antigen antibody
Leukocyte L1 complex light chain antibody
Migration inhibitory factor-related protein 8 antibody
MRP-8 antibody
N-terminally processed antibody
p8 antibody
Protein S100-A8 antibody
展开图片
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mIHC analysis of mouse spleen tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-S100A8+S100A9 antibody (IRS196RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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