cIAP2 Recombinant Rabbit Monoclonal Antibody [PSH06-92]
Catalog# HA722767
cIAP2 Recombinant Rabbit Monoclonal Antibody [PSH06-92]
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WB
-
Human
-
HA751116
不含抗保成分
-
unconjugated
概述
产品名称
cIAP2 Recombinant Rabbit Monoclonal Antibody [PSH06-92]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within human cIAP2 aa 205-604.
种属反应性
Human
验证应用
WB
分子量
Predicted band size: 68 kDa
阳性对照
Raji cell lysate, Daudi cell lysate, Ramos cell lysate, NCI-H1299 cell lysate.
偶联
unconjugated
克隆号
PSH06-92
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:2,000
靶点
功能
Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.
背景文献
1. Glasheen MQ et al. Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma. Mol Cancer Ther. 2023 Sep
2. Ding Z et al. cIAP2 expression and clinical significance in pigmented villonodular synovitis. J Mol Histol. 2021 Apr
亚细胞定位
Cytoplasm, Nucleus.
UNIPROT
别名
AIP 1 antibody
AIP1 antibody
API 2 antibody
API2 antibody
Apoptosis inhibitor 2 antibody
Baculoviral IAP repeat containing 3 antibody
Baculoviral IAP repeat containing protein 3 antibody
Baculoviral IAP repeat-containing protein 3 antibody
BIRC 3 antibody
BIRC3 antibody
展开图片
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Western blot analysis of cIAP2 on different lysates with Rabbit anti-cIAP2 antibody (HA722767) at 1/2,000 dilution.
Lane 1: Raji cell lysate
Lane 2: Daudi cell lysate
Lane 3: Ramos cell lysate
Lane 4: NCI-H1299 cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 68 kDa
Observed band size: 70 kDa
Exposure time: 3 minutes; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722767) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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