CCR9 Recombinant Rabbit Monoclonal Antibody [JE00-35]
Catalog# HA722444
CCR9 Recombinant Rabbit Monoclonal Antibody [JE00-35]
-
WB
-
Human
-
Mouse
-
Rat
-
unconjugated
概述
产品名称
CCR9 Recombinant Rabbit Monoclonal Antibody [JE00-35]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within Human CCR9 aa 1-100 / 369.
种属反应性
Human, Mouse, Rat
验证应用
WB
分子量
Predicted band size: 42 kDa
阳性对照
A549 cell lysate, Jurkat cell lysate, HepG2 cell lysate, mouse thymus tissue lysate, rat lung tissue lysate, rat thymus tissue lysate.
偶联
unconjugated
克隆号
JE00-35
反应性数据
| WB | |
|---|---|
| Human |
|
| Mouse |
|
| Rat |
|
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:1,000
靶点
功能
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene.
背景文献
1. Wu X et al. The Roles of CCR9/CCL25 in Inflammation and Inflammation-Associated Diseases. Front Cell Dev Biol. 2021 Aug
2. Jamal M et al. CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis. Front Pharmacol. 2023 Sep
亚细胞定位
Cell membrane.
别名
C C chemokine receptor D6 antibody
C C chemokine receptor type 9 antibody
C C CKR 9 antibody
C-C chemokine receptor type 9 antibody
C-C CKR-9 antibody
CC Chemokine receptor CCR10 antibody
CC CKR 9 antibody
CC-CKR-9 antibody
CCBP2 antibody
CCCKR9 antibody
展开图片
-
Western blot analysis of CCR9 on different lysates with Rabbit anti-CCR9 antibody (HA722444) at 1/1,000 dilution.
Lane 1: A549 cell lysate (20 µg/Lane)
Lane 2: Jurkat cell lysate (20 µg/Lane)
Lane 3: HepG2 cell lysate (20 µg/Lane)
Lane 4: Mouse thymus tissue lysate (40 µg/Lane)
Lane 5: Rat lung tissue lysate (40 µg/Lane)
Lane 6: Rat thymus tissue lysate (40 µg/Lane)
Predicted band size: 42 kDa
Observed band size: 42 kDa
Exposure time: 1 minute 50 seconds; ECL: K1802;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722444) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
浙公网安备 33019202000643号