Oxytocin-neurophysin 1 / OXT Recombinant Antibody [PSH08-24] - Rat IgG1 (Chimeric) - BSA and Azide free
Rmb: 5600
Catalog# HA610266
Oxytocin-neurophysin 1 / OXT Recombinant Antibody [PSH08-24] - Rat IgG1 (Chimeric) - BSA and Azide free
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IHC-Fr
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IHC-P
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IF-Tissue
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Mouse
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Rat
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HA601426
含抗保成分
-
Human
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Cynomolgus monkey
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Pig
预测的种属支持售后
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unconjugated
概述
产品名称
Oxytocin-neurophysin 1 / OXT Recombinant Antibody [PSH08-24] - Rat IgG1 (Chimeric) - BSA and Azide free
抗体类型
Recombinant Chimeric Antibody
免疫原
Recombinant protein within human OXT aa 1-125.
种属反应性
Mouse, Rat (Predicted: Human, Cynomolgus monkey, Pig)
预测的种属支持售后
验证应用
IHC-Fr, IHC-P, IF-Tissue
靶点分子量
Predicted band size: 13 kDa
阳性对照
Mouse pituitary tissue, rat pituitary tissue, mouse paraventricular nucleus tissue.
偶联
unconjugated
克隆号
PSH08-24
产品特性
形态
Liquid
浓度
存放说明
Store at 2-8℃. Avoid freeze.
存储缓冲液
1*PBS (pH7.4).
纯化方式
Protein A affinity purified.
应用稀释度
靶点
功能
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during childbirth. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. In its natural form, it also plays a role in maternal bonding and milk production. Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases. A similar process takes place during lactation and during sexual activity.
背景文献
1. De Leon D et al. Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques. Horm Behav. 2020 Nov
2. Khazaal NM et al. The relationship between OXT gene polymorphisms and reproductive hormones in pregnant and lactating Awassi Ewes. Mol Biol Rep. 2023 Oct
亚细胞定位
Secreted.
别名
MGC126890 antibody
MGC126892 antibody
Neurophysin 1 antibody
Neurophysin I antibody
Ocytocin antibody
OT antibody
OT NPI antibody
OXT antibody
Oxytocin antibody
Oxytocin Neurophysin preproprotein antibody
展开图片
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This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Application: IHC-Fr
Species: Mouse
Site: Paraventricular nucleus
Sample: Frozen section
Antibody concentration: 1/500
Antigen retrieval: Not required -
This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Application: IF-tissue
Species: Mouse
Site: Paraventricular nucleus
Sample: Paraffin-embedded section
Antibody concentration: 1/500 -
This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Application: IF-tissue
Species: Mouse
Site: Pituitary
Sample: Paraffin-embedded section
Antibody concentration: 1/500 -
This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Application: IF-tissue
Species: Rat
Site: Pituitary
Sample: Paraffin-embedded section
Antibody concentration: 1/500 -
This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Immunohistochemical analysis of paraffin-embedded mouse pituitary tissue with Rat anti-Oxytocin-neurophysin 1 / OXT antibody (HA601426) at 1/5,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA601426) at 1/5,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
This data was developed using HA601426, the same antibody clone in a different buffer formulation.
Immunohistochemical analysis of paraffin-embedded rat pituitary tissue with Rat anti-Oxytocin-neurophysin 1 / OXT antibody (HA601426) at 1/5,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA601426) at 1/5,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
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