GFAP Rabbit Polyclonal Antibody

功能

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. In addition, GFAP intermediate filaments are also present in nonmyelin-forming Schwann cells in the peripheral nervous system.

背景文献

1. "A new splice variant of glial fibrillary acidic protein GFAPepsilon, interacts with the presenilin proteins." Nielsen A.L., Holm I.E., Johansen M., Bonven B., Jorgensen P., Jorgensen A.L. J. Biol. Chem. 277:29983-29991(2002)

2. "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease." Brenner M., Johnson A.B., Boespflug-Tanguy O., Rodriguez D., Goldman J.E., Messing A. Nat. Genet. 27:117-120(2001)

序列相似性

Belongs to the intermediate filament family.

组织特异性

Expressed in cells lacking fibronectin.

翻译后修饰

Phosphorylated by PKN1.

亚细胞定位

Cytoplasm, Intermediate filament.

UNIPROT

SwissProt: P14136 Human

SwissProt: P03995 Mouse

SwissProt: P47819 Rat

别名