COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
Catalog# RE6064
COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
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WB
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IF-Cell
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Human
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Mouse
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unconjugated
概述
产品名称
COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
peptide
种属反应性
Human, Mouse
验证应用
WB, IF-Cell
分子量
72kDa
阳性对照
Raw264.7
偶联
unconjugated
克隆号
6J8
产品特性
形态
Liquid
浓度
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
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1:1,000
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IF-Cell
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1:100
靶点
功能
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general "housekeeping" functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.
背景文献
1. Hsu CK et al. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. J Cell Physiol 230:702-15 (2015).
2. Zhao L et al. Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. PLoS One 10:e0139978 (2015).
亚细胞定位
Microsome membrane,Endoplasmic reticulum membrane
UNIPROT
别名
COX 2 antibody
COX-2 antibody
COX2 antibody
Cyclooxygenase 2 antibody
Cyclooxygenase 2b antibody
Cyclooxygenase antibody
Cyclooxygenase-2 antibody
Cyclooxygenase2 antibody
EC 1.14.99.1 antibody
fj02a10 antibody
展开图片
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Western blot analysis on Raw264.7 cell lysate + LPS using anti-COX2.
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Immunocytochemical analysis of paraffin-embedded Raw264.7 cells using anti-COX2.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
引文
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Araloside A alleviates sepsis-induced acute lung injury via PHD2/HIF-1α in macrophages.
期刊: Phytomedicine
DOI:
IF: 6.7
应用: WB
反应种属:
发表时间: 2024 Sep
Alternative Products
COX2 Recombinant Rabbit Monoclonal Antibody [SC56-06]
Application: WB,IF-Cell,IF-Tissue,IHC-P
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
同靶点 & 同通路的产品
COX2 Mouse Monoclonal Antibody [A3F7]
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COX2 Mouse Monoclonal Antibody [A3F8]
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Reactivity: Human,Rat
Conjugate: unconjugated
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