CD276 Mouse Monoclonal Antibody [C10-A1]
Catalog# EM1709-85
CD276 Mouse Monoclonal Antibody [C10-A1]
-
WB
-
IHC-P
-
FC
-
Human
概述
产品名称
CD276 Mouse Monoclonal Antibody [C10-A1]
抗体类型
Mouse Monoclonal Antibody
免疫原
Recombinant protein
种属反应性
Human
验证应用
WB, IHC-P, FC
分子量
57 kDa
阳性对照
CD276-hIgGFc transfected HEK293 cell lysate, human cervical cancer tissue, human ovarian cancer tissue, PC-3.
偶联
unconjugated
克隆号
C10-A1
产品特性
形态
Liquid
浓度
2ug/ul
存放说明
4℃; -20℃ for long term storage.
存储缓冲液
Purified antibody in PBS with 0.05% sodium azide.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:500-1:2,000
-
IHC-P
-
1:200-1:1,000
-
FC
-
1:200-1:400
靶点
功能
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 Immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.
背景文献
1. Seaman S et al. Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell 31:501-515.e8 (2017).
2. Wilson KE et al. Spectroscopic Photoacoustic Molecular Imaging of Breast Cancer using a B7-H3-targeted ICG Contrast Agent. Theranostics 7:1463-1476 (2017).
亚细胞定位
Membrane.
UNIPROT
别名
4Ig B7 H3 antibody
4Ig-B7-H3 antibody
AU016588 antibody
B7 H3 antibody
B7 homolog 3 antibody
B7-H3 antibody
B7H3 antibody
B7RP-2 antibody
CD_antigen=CD276 antibody
CD276 antibody
展开图片
-
Western blot analysis of CD276 on HEK293 (1) and CD276-hIgGFc transfected HEK293 (2) cell lysate using anti-CD276 antibody at 1/1,000 dilution.
-
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-CD276 antibody. Counter stained with hematoxylin.
-
Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-CD276 antibody. Counter stained with hematoxylin.
-
Flow cytometric analysis of PC-3 cells with CD276 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
CD276 Recombinant Rabbit Monoclonal Antibody [PSH02-46]
Application: WB,IF-Cell,FC
Reactivity: Human
Conjugate: unconjugated
CD276 Recombinant Rabbit Monoclonal Antibody [PD00-36]
Application: IHC-P,FC,WB
Reactivity: Human
Conjugate: unconjugated
同靶点 & 同通路的产品
CD276 Recombinant Rabbit Monoclonal Antibody [PSH02-46]
Application: WB,IF-Cell,FC
Reactivity: Human
Conjugate: unconjugated
CD276 Rabbit Polyclonal Antibody
Application: WB,IF-Cell
Reactivity: Human
Conjugate: unconjugated