CD105 Mouse Monoclonal Antibody [A5E8]
Catalog# HA600077
CD105 Mouse Monoclonal Antibody [A5E8]
-
WB
-
Human
概述
产品名称
CD105 Mouse Monoclonal Antibody [A5E8]
抗体类型
Mouse Monoclonal Antibody
免疫原
Recombinant protein within human CD105 aa 101-300.
种属反应性
Human
验证应用
WB
分子量
Predicted band size: 71 kDa
阳性对照
Hela cell lysate, HepG2 cell lysate.
偶联
unconjugated
克隆号
A5E8
RRID
产品特性
形态
Liquid
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG2b
纯化方式
Protein G affinity purified.
应用稀释度
-
WB
-
1:500
靶点
功能
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
背景文献
1. Wang X. et. al. CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway. J Cancer. 2020 Jan
2. Kauer J. et. al. CD105 (Endoglin) as negative prognostic factor in AML. Sci Rep. 2019 Dec
亚细胞定位
Cell membrane.
UNIPROT
别名
AI528660 antibody
AI662476 antibody
CD 105 antibody
CD105 antibody
CD105 antigen antibody
EGLN_HUMAN antibody
END antibody
Endoglin antibody
Eng antibody
FLJ41744 antibody
展开图片
-
Western blot analysis of CD105 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA600077, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:20,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
同靶点 & 同通路的产品
CD105 Rabbit Polyclonal Antibody
Application: WB,IHC-P
Reactivity: Human
Conjugate: unconjugated
CD105 Recombinant Rabbit Monoclonal Antibody [JE60-59]
Application: WB,IHC-P,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
