CD105 Mouse Monoclonal Antibody [H4-A9]
Catalog# EM1709-99
CD105 Mouse Monoclonal Antibody [H4-A9]
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WB
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IF-Cell
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IHC-P
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FC
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Human
概述
产品名称
CD105 Mouse Monoclonal Antibody [H4-A9]
抗体类型
Mouse Monoclonal Antibody
免疫原
Recombinant protein
种属反应性
Human
验证应用
WB, IF-Cell, IHC-P, FC
分子量
71 kDa
阳性对照
CD105-hIgGFc transfected HEK293 cell lysate, HepG2, human kidney cancer tissue, human stomach cancer tissue.
偶联
unconjugated
克隆号
H4-A9
产品特性
形态
Liquid
存放说明
4℃; -20℃ for long term storage.
存储缓冲液
Purified antibody in PBS with 0.05% sodium azide.
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
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WB
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1:500-1:1,000
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IF-cell
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1:100-1:500
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IHC-P
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1:100-1:500
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FC
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1:100-1:200
靶点
功能
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by vascular abnormalities such as dilated vessels, hemorrhages, liver and lung congestion, and brain or heart ischemia. Mutations in two genes, Endoglin (also designated CD105) and ALK-1 (Activin receptor-like kinase 1, also designated TGFβ superfamily RI), are responsible for HHT. Endoglin is mutated in HHT1, and ALK-1 is mutated in HHT2, both of which are thought to be caused by haploinsufficiency. Endoglin and ALK-1 are type III and type I members of the TGFβ receptor superfamily, respectively, that are expressed on vascular endothelial cells. Endoglin can only bind ligands of the TGFβ superfamily via association with the respective ligand binding receptors for TGFβ1, TGFβ3, Activin-A, BMP-2 and BMP-7.
背景文献
暂无
亚细胞定位
Membrane.
UNIPROT
别名
AI528660 antibody
AI662476 antibody
CD 105 antibody
CD105 antibody
CD105 antigen antibody
EGLN_HUMAN antibody
END antibody
Endoglin antibody
Eng antibody
FLJ41744 antibody
展开图片
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Western blot analysis of CD105 on HEK293 (1) and CD105-hIgGFc transfected HEK293 (2) cell lysate using anti-CD105 antibody at 1/1,000 dilution.
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ICC staining CD105 (green) and actin filaments (red) in HepG2 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Immunohistochemical analysis of paraffin-embedded human kidney cancer tissue using anti-CD105 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-CD105 antibody. Counter stained with hematoxylin.
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Flow cytometric analysis of HepG2 cells with CD105 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
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同靶点 & 同通路的产品
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CD105 Recombinant Rabbit Monoclonal Antibody [JE60-59]
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Conjugate: unconjugated