B7-H4(VTCN1) Rabbit Polyclonal Antibody

功能

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

背景文献

1. Huang H et al. Clinical significance of the B7-H4 as a novel prognostic marker in breast cancer. Gene 623:24-28 (2017).

2. Bregar A et al. Characterization of immune regulatory molecules B7-H4 and PD-L1 in low and high grade endometrial tumors.Gynecol Oncol 145(3):446-452 (2017).

序列相似性

Belongs to the immunoglobulin superfamily. BTN/MOG family.

组织特异性

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

翻译后修饰

N-glycosylated.

亚细胞定位

Cell membrane.

UNIPROT

SwissProt: Q7Z7D3 Human

SwissProt: Q7TSP5 Mouse

别名