ATG12 Rabbit Polyclonal Antibody

功能

Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy. Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine. Atg12 was found to be involved in apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family.

背景文献

1. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E. J. Biol. Chem. 277:13739-13744(2002)

2. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate." Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q. Mol. Cell 45:629-641(2012)

3. "Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy." Otomo C., Metlagel Z., Takaesu G., Otomo T. Nat. Struct. Mol. Biol. 20:59-66(2013)

序列相似性

Belongs to the ATG12 family.

组织特异性

Ubiquitous.

翻译后修饰

Acetylated by EP300.

亚细胞定位

Cytoplasm

UNIPROT

SwissProt: O94817 Human

别名