NSE Rabbit Polyclonal Antibody

功能

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.

背景文献

1. Fujiwara H, Arima N, Ohtsubo H et al. (2002). "Clinical significance of serum neuron-specific enolase in patients with adult T-cell leukemia". Am. J. Hematol. 71 (2): 80–4.

2. Nakatsuka S, Nishiu M, Tomita Y et al. (2005). "Enhanced expression of neuron-specific enolase (NSE) in pyothorax-associated lymphoma (PAL)". Jpn. J. Cancer Res. 93 (4): 411–6.

3. Chekhonin VP, Zhirkov YA, Belyaeva IA et al. (2002). "Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease". Clin. Chim. Acta 320 (1–2): 117–25.

序列相似性

Belongs to the enolase family.

组织特异性

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

亚细胞定位

Cytoplasm, cell membrane

UNIPROT

SwissProt: P09104 Human

别名