Human CD3 Recombinant Mouse Monoclonal Antibody [PSH04-92]
Catalog# HA601337
Human CD3 Recombinant Mouse Monoclonal Antibody [PSH04-92]
-
FC
-
Human
概述
产品名称
Human CD3 Recombinant Mouse Monoclonal Antibody [PSH04-92]
抗体类型
Recombinant Mouse Monoclonal Antibody
免疫原
Recombinant protein within
种属反应性
Human
验证应用
FC
分子量
Predicted band size: 23 kDa
阳性对照
Human peripheral blood lymphocytes.
偶联
unconjugated
克隆号
PSH04-92
产品特性
形态
Liquid
浓度
1ug/ul
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
PBS (pH7.4).
亚型
IgG1
纯化方式
Protein A affinity purified.
应用稀释度
-
FC
-
1:1,000
靶点
功能
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
背景文献
1. LeFevre JD et al. Anti-CD3 monoclonal antibodies for the prevention and treatment of type 1 diabetes: A literature review. Am J Health Syst Pharm. 2022 Nov
2. Chen Y et al. Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Mol Cell. 2022 Apr
亚细胞定位
Cell membrane.
UNIPROT
别名
CD3 epsilon antibody
CD3e antibody
CD3e antigen antibody
CD3e antigen epsilon polypeptide (TiT3 complex) antibody
CD3E antigen epsilon polypeptide antibody
CD3E antigen, epsilon subunit antibody
CD3e molecule epsilon antibody
CD3e molecule, epsilon (CD3 TCR complex) antibody
CD3e molecule, epsilon (CD3-TCR complex) antibody
CD3E_HUMAN antibody
展开图片
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Flow cytometric analysis of human peripheral blood lymphocytes labeling Human CD3.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601337, 1μg/mL) (red). After incubation of the primary antibody at +4℃ for 30 minutes, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1125) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
同靶点 & 同通路的产品
APC Conjugated Human CD3 Recombinant Mouse Monoclonal Antibody [PSH04-92]
Application: FC
Reactivity: Human
Conjugate: APC
PE Conjugated Human CD3 Recombinant Mouse Monoclonal Antibody [PSH04-92]
Application: FC
Reactivity: Human
Conjugate: PE
