TRIP6 Mouse Monoclonal Antibody [G1-H4]

功能

Zyxin is a LIM domain-containing, zinc finger domain-containing, SH3 ligand-containing phosphoprotein that localizes to focal adhesion plaques and actin filament bundles. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein. TRIP6 interacts with the ligand binding domain of the thyroid receptor and is predominantly expressed in kidney, liver and lung. It interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a TNF- or IL-1-dependent manner. TRIP6 also interacts with TRAF2, a protein that is crucially involved in TNF signaling, as well as the IL-1 receptor, TLR2 and Nod1. Overexpression of TRIP6 facilitates NFkappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NFkappaB activation by TNF, IL-1, TLR2 or Nod1. Moreover, TRIP6 also potentiates RIP2- and Nod1-mediated ERK activation.

背景文献

1. Willier S et al. Defining the role of TRIP6 in cell physiology and cancer. Biol Cell 103(12):573-91 (2011).

2. Lai YJ et al. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration. Mol Cell Biol 30(23):5582-96 (2010).

亚细胞定位

Cytoplasm. Cell junction. Nucleus.

UNIPROT

SwissProt: Q15654 Human

别名