TMEM106C Rabbit Polyclonal Antibody
Catalog# HA500625
TMEM106C Rabbit Polyclonal Antibody
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IHC-P
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Human
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unconjugated
概述
产品名称
TMEM106C Rabbit Polyclonal Antibody
抗体类型
Rabbit Polyclonal Antibody
种属反应性
Human
验证应用
IHC-P
分子量
Predicted band size: 28 kDa
阳性对照
Human liver cancer tissue, human parathyroid gland tissue.
偶联
unconjugated
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
亚型
IgG
纯化方式
Immunogen affinity purified.
应用稀释度
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IHC-P
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1:500-1:2,000
靶点
功能
TMEM106C is a gene that encodes the transmembrane protein 106C (TMEM106C) in Homo sapiens It has been found to be overexpressed in cancer cells and also is related to distal arthrogryposis, a condition of stiff joints and irregular muscle development. The TMEM106C gene contains a domain of unknown function, DUF1356, that spans most of the protein. Transmembrane protein 106C also goes by the aliases MGC5576 or MGC111210, LOC79022.
背景文献
1. Duan J et al. TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma. Aging (Albany NY). 2021 Feb
2. Jiang C et al. LINC00238 inhibits hepatic carcinoma progression by activating TMEM106C-mediated apoptosis pathway. Mol Med Rep. 2021 Nov
亚细胞定位
Endoplasmic reticulum membrane, Membrane.
UNIPROT
别名
Transmembrane protein 106C
Endoplasmic reticulum membrane protein overexpressed in cancer
TMEM106C
EMOC
图片
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Immunohistochemical analysis of paraffin-embedded human liver cancer tissue with Rabbit anti-TMEM106C antibody (HA500625) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA500625) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded human parathyroid gland tissue with Rabbit anti-TMEM106C antibody (HA500625) at 1/500 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA500625) at 1/500 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
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