PLA2G12A Mouse Monoclonal Antibody [C11-H2]

功能

Secreted phospholipases A2 (sPLA2s) form a large family of structurally related enzymes, which are widespread in nature. Snake venoms have been known for decades to contain a tremendous molecular diversity of sPLA2s, which can exert a myriad of toxic and pharmacological effects. Secreted phospholipase A2 enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as group XIIA sPLA2, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s. Group XIIA sPLA2, also known as GXII, ROSSY, PLA2G12 or PLA2G12A, is a 189 amino acid secreted protein that localizes to the cytoplasm. Belonging to the phospholipase A2 family, group XIIA sPLA2 is abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas

背景文献

1. Murakami M et al. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). J Biol Chem. 2003 Mar 21;278(12):10657-67.

2. Rouault M et al. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Biochemistry. 2003 Oct 7;42(39):11494-503.

亚细胞定位

Secreted. Cytoplasm

UNIPROT

SwissProt: Q9BZM1 Human

别名