MMP-9 Recombinant Mouse Monoclonal Antibody [10A1]

功能

Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.MMP9 plays several important functions within neutrophil action, such as degrading extracellular matrix, activation of IL-1β, and cleavage of several chemokines. In a mouse model, MMP9 deficiency resulted in resistance to endotoxin shock, suggesting that MMP9 is important in sepsis.

背景文献

1. Park JH et al. Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model. Mar Drugs 15:(4) pii: E112. (2017).

2. Chen X et al. The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Sci Rep 7:40958 (2017).

序列相似性

Belongs to the peptidase M10A family.

组织特异性

Detected in neutrophils (at protein level). Produced by normal alveolar macrophages and granulocytes.

翻译后修饰

Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.; N- and O-glycosylated.

亚细胞定位

Secreted.

UNIPROT

SwissProt: P14780 Human

别名