ST2 Rabbit Polyclonal Antibody

功能

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

背景文献

1. Zhao, G., Ji, H., Wang, S., Gu, B., Song, X., Zhang, J., Zhang, M. (2014). Cell surface proteomics analysis indicates a neural lineage bias of rat bone marrow mesenchymal stromal cells. Biomed Res Int, 2014, 479269.

序列相似性

Belongs to the interleukin-1 receptor family.

组织特异性

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.

亚细胞定位

Cell membrane, Secreted.

UNIPROT

SwissProt: Q01638 Human

SwissProt: P14719 Mouse

别名