Biotin Conjugated Human CD85d Recombinant Rabbit Monoclonal Antibody [PSH05-62]
概述
产品名称
Biotin Conjugated Human CD85d Recombinant Rabbit Monoclonal Antibody [PSH05-62]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within human CD85d aa 22-460 (Extracellular).
种属反应性
Human
验证应用
ELISA(Det)
阳性对照
Recombinant standard Human CD85d protein (HA210643).
偶联
Biotin
克隆号
PSH05-62
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% ProClin300.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
ELISA(Det)
-
Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH05-61] to Human CD85d (Capture) (HA722381) and recombinant standard Human CD85d protein (HA210643). The reference range value is 61.7-15000 pg/ml.
靶点
功能
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
背景文献
1. Koestlin N., Ostermeir A.L., Spring B., Schwarz J., Marme A., Walter C.B., Poets C.F., Gille C. HLA-G promotes myeloid-derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4. Eur. J. Immunol. 47:374-384 (2017).
2. Gregori S., Tomasoni D., Pacciani V., Scirpoli M., Battaglia M., Magnani C.F., Hauben E., Roncarolo M.G.. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 116:935-944 (2010).
亚细胞定位
Cell membrane.
UNIPROT
别名
CD85 antigen-like family member D antibody
CD85d antibody
CD85d antigen antibody
ILT 4 antibody
ILT-4 antibody
ILT4 antibody
Immunoglobulin like transcript 4 antibody
Immunoglobulin-like transcript 4 antibody
Leukocyte immunoglobulin like receptor 2 antibody
Leukocyte immunoglobulin like receptor subfamily B member 2 antibody
展开图片
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
同靶点 & 同通路的产品
Human CD85d Recombinant Rabbit Monoclonal Antibody [PSH05-62] - BSA and Azide free (Detector)
Application: ELISA(Det)
Reactivity: Human
Conjugate: unconjugated
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