GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
Catalog# HA722551
GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
-
WB
-
Human
-
unconjugated
概述
产品名称
GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
抗体类型
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide within human GDF15 aa 241-290 / 308.
种属反应性
Human
验证应用
WB
分子量
Predicted band size: 34 kDa
阳性对照
HepG2 cell lysate, SK-MEL-28 cell lysate, LNCaP cell lysate.
偶联
unconjugated
克隆号
JE39-90
反应性数据
| WB | |
|---|---|
| Human |
|
| Mouse |
|
| Rat |
|
产品特性
形态
Liquid
浓度
存放说明
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
存储缓冲液
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
亚型
IgG
纯化方式
Protein A affinity purified.
应用稀释度
-
WB
-
1:2,000
靶点
功能
Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 was first identified as Macrophage inhibitory cytokine-1 or MIC-1. It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as liver, kidney, heart and lung. The function of GDF15 is not fully clear but it seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, angiogenesis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders.
背景文献
1. Wang D et al. GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nat Rev Endocrinol. 2021 Oct
2. Johann K et al. The Role of GDF15 as a Myomitokine. Cells. 2021 Nov
亚细胞定位
Secreted.
UNIPROT
别名
GDF 15 antibody
GDF-15 antibody
Gdf15 antibody
GDF15_HUMAN antibody
Growth differentiation factor 15 antibody
Growth/differentiation factor 15 antibody
Macrophage inhibitory cytokine 1 antibody
MIC 1 antibody
Mic-1 antibody
MIC1 antibody
展开图片
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Western blot analysis of GDF15 on different lysates with Rabbit anti-GDF15 antibody (HA722551) at 1/1,000 dilution.
Lane 1: HepG2 cell lysate
Lane 2: SK-MEL-28 cell lysate
Lane 3: LNCaP cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 34 kDa
Observed band size: 34/12.5 kDa
Exposure time: 25 seconds; ECL: K1802;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722551) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
同靶点 & 同通路的产品
GDF15 Recombinant Rabbit Monoclonal Antibody [PSH10-09] - BSA and Azide free
Application: WB,IHC-P
Reactivity: Human
Conjugate: unconjugated
GDF15 Rabbit Polyclonal Antibody
Application: WB
Reactivity: Mouse,Rat
Conjugate: unconjugated
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