CEBP alpha Recombinant Rabbit Monoclonal Antibody [SD202-09]

功能

The transcription factor C/EBP α (CCAAT-enhancer binding protein) is a heat-stable, sequence-specific DNA-binding protein that binds avidly to several different cis-regulatory DNA sequences commonly associated with viral and cellular genes transcribed by RNA polymerase II. C/EBP α regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP α is a basic region/leucine zipper transcription factor selectively expressed during the differentiation of liver, adipose tissue, blood cells and the endocrine pancreas. C/EBP α uses a bipartite structural motif to bind DNA and appears to function exclusively in terminally differentiated, growth-arrested cells. In the liver, C/EBP α is a transactivator of several genes, which are regulated by growth hormone. Growth hormone enhances not only the levels of C/EBP α mRNA and protein, but also the DNA binding activity of C/EBP α. C/EBP α functions as an important transcription factor that regulates different genes, including prolactin gene expression.

背景文献

1. Christou-Kent M et al. CEBPA phase separation links transcriptional activity and 3D chromatin hubs. Cell Rep. 2023 Aug

2. Georgi JA et al. Prognostic impact of CEBPA mutational subgroups in adult AML. Leukemia. 2024 Feb

序列相似性

Belongs to the bZIP family. C/EBP subfamily.

翻译后修饰

Phosphorylation at Ser-190 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition. Dephosphorylated at Ser-190 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation. Phosphorylation at Thr-226 and Thr-230 by GSK3 is constitutive in adipose tissue and lung. In liver, both Thr-226 and Thr-230 are phosphorylated only during feeding but not during fasting. Phosphorylation of the GSK3 consensus sites selectively decreases transactivation activity on IRE-controlled promoters.; Sumoylated, sumoylation blocks the inhibitory effect on cell proliferation by disrupting the interaction with SMARCA2.; Ubiquitinated by COP1 upon interaction with TRIB1.

亚细胞定位

Nucleus, nucleolus.

UNIPROT

SwissProt: P49715 Human

SwissProt: P53566 Mouse

SwissProt: P05554 Rat

别名