CD16 Mouse Monoclonal Antibody [Q32]
Catalog# EM60067
CD16 Mouse Monoclonal Antibody [Q32]
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WB
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IHC-P
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Human
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unconjugated
概述
产品名称
CD16 Mouse Monoclonal Antibody [Q32]
抗体类型
Mouse Monoclonal Antibody
免疫原
Synthetic Peptide of CD16
种属反应性
Human
验证应用
WB, IHC-P
分子量
45 kDa
阳性对照
Lung,Placenta,
偶联
unconjugated
克隆号
Q32
产品特性
形态
Liquid
浓度
存放说明
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
存储缓冲液
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
亚型
IgG1
纯化方式
Immunogen affinity purified.
应用稀释度
-
WB
-
1:1000
-
IHC-P
-
1:50-300
靶点
功能
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,
背景文献
1. Mizushima T. et al. Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans. Genes Cells 16:1071-1080(2011).
2. Ferrara C. et al. Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc. Natl. Acad. Sci. U.S.A. 108:12669-12674(2011).
亚细胞定位
Cell membrane, Secreted.
别名
CD 16 antibody
CD 16a antibody
CD16 antibody
CD16a antibody
CD16a antigen antibody
CD16B antibody
CD16b antigen antibody
Fc fragment of IgG antibody
Fc fragment of IgG low affinity IIIa receptor (CD16) antibody
Fc fragment of IgG low affinity IIIa receptor antibody
展开图片
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Immunohistochemical analysis of paraffin-embedded Human-liver tissue. 1,CD16 Monoclonal Antibody(Q32) was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min). Negative control was used by secondary antibody only.
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Western blot analysis of 1) Jurkat, 2) K562, diluted at 1:2000.
请注意: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
CD16 Recombinant Rabbit Monoclonal Antibody [PD00-12]
Application: IHC-P,IF-Tissue,IF-Cell,mIHC,WB
Reactivity: Human
Conjugate: unconjugated
CD16 Recombinant Rabbit Monoclonal Antibody [JE49-79]
Application: WB
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
同靶点 & 同通路的产品
CD16 Recombinant Rabbit Monoclonal Antibody [PD00-12]
Application: IHC-P,IF-Tissue,IF-Cell,mIHC,WB
Reactivity: Human
Conjugate: unconjugated
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